Response to comments of Peter G. Mantle

Gary G. Schwartz, Richard A. Manderville, Annie Pfohl-Leszkowicz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The apparently high yield of testis tumors (25%) in rats exposed long-term to Ochratoxin A (OTA) is uninterpretable without data on tumor yield in unexposed rats. Conversely, our demonstration that prenatal exposure to OTA induces DNA adducts in the testes of newborn mice and the absence of these adducts in the testes of mice not exposed prenatally to OTA, is evidence for the presumptive carcinogenicity of OTA in the testis. Together with recent data showing that prenatal exposure to OTA depresses expression of DMRT1, a tumor suppressor gene in the testis, our findings suggest that OTA may be a cause of testicular cancer.

Original languageEnglish (US)
Pages (from-to)2337-2339
Number of pages3
Issue number10
StatePublished - Oct 2010
Externally publishedYes


  • Dna adduct
  • Ochratoxin
  • Testicular cancer

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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