Response to comments of Peter G. Mantle

Gary G. Schwartz, Richard A. Manderville, Annie Pfohl-Leszkowicz

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The apparently high yield of testis tumors (25%) in rats exposed long-term to Ochratoxin A (OTA) is uninterpretable without data on tumor yield in unexposed rats. Conversely, our demonstration that prenatal exposure to OTA induces DNA adducts in the testes of newborn mice and the absence of these adducts in the testes of mice not exposed prenatally to OTA, is evidence for the presumptive carcinogenicity of OTA in the testis. Together with recent data showing that prenatal exposure to OTA depresses expression of DMRT1, a tumor suppressor gene in the testis, our findings suggest that OTA may be a cause of testicular cancer.

Original languageEnglish (US)
Pages (from-to)2337-2339
Number of pages3
JournalToxins
Volume2
Issue number10
DOIs
StatePublished - Oct 2010

Keywords

  • Dna adduct
  • Ochratoxin
  • Testicular cancer

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Schwartz, G. G., Manderville, R. A., & Pfohl-Leszkowicz, A. (2010). Response to comments of Peter G. Mantle. Toxins, 2(10), 2337-2339. https://doi.org/10.3390/toxins2102337