Response to Fungal Dysbiosis by Gut-Resident CX3CR1                         +                          Mononuclear Phagocytes Aggravates Allergic Airway Disease

Xin Li; Irina Leonardi; Alexa Semon; Itai Doron; Iris H. Gao; Gregory Garbès Putzel; Youngjun Kim; Hiroki Kabata; David Artis; William D. Fiers; Amanda E. Ramer-Tait; Iliyan D. Iliev

doi:10.1016/j.chom.2018.11.003

Response to Fungal Dysbiosis by Gut-Resident CX3CR1 ⁺ Mononuclear Phagocytes Aggravates Allergic Airway Disease

Xin Li, Irina Leonardi, Alexa Semon, Itai Doron, Iris H. Gao, Gregory Garbès Putzel, Youngjun Kim, Hiroki Kabata, David Artis, William D. Fiers, Amanda E. Ramer-Tait, Iliyan D. Iliev

Food Science and Technology

Research output: Contribution to journal › Article

29 Scopus citations

Abstract

How mycobiota influence immunity in gut distal sites is not well understood. Li et al. developed protocols for gut-targeted depletion of phagocytes and mycobiota-free mice to investigate the influence of fungi on gut-lung crosstalk. They reveal that intestinal phagocytes sense fungal dysbiosis and mediate gut-lung-directed immunity to aggravate allergic airway disease.

Original language	English (US)
Pages (from-to)	847-856.e4
Journal	Cell Host and Microbe
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2018.11.003
State	Published - Dec 12 2018

Keywords

CX3CR1 mononuclear phagocytes
fungi
gut-lung axis
mycobiome
mycobiota dysbiosis

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

Access to Document

10.1016/j.chom.2018.11.003

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Li, X., Leonardi, I., Semon, A., Doron, I., Gao, I. H., Putzel, G. G., Kim, Y., Kabata, H., Artis, D., Fiers, W. D., Ramer-Tait, A. E., & Iliev, I. D. (2018). Response to Fungal Dysbiosis by Gut-Resident CX3CR1 ⁺ Mononuclear Phagocytes Aggravates Allergic Airway Disease Cell Host and Microbe, 24(6), 847-856.e4. https://doi.org/10.1016/j.chom.2018.11.003

Response to Fungal Dysbiosis by Gut-Resident CX3CR1 ⁺ Mononuclear Phagocytes Aggravates Allergic Airway Disease . / Li, Xin; Leonardi, Irina; Semon, Alexa; Doron, Itai; Gao, Iris H.; Putzel, Gregory Garbès; Kim, Youngjun; Kabata, Hiroki; Artis, David; Fiers, William D.; Ramer-Tait, Amanda E.; Iliev, Iliyan D.

In: Cell Host and Microbe, Vol. 24, No. 6, 12.12.2018, p. 847-856.e4.

Research output: Contribution to journal › Article

Li, X, Leonardi, I, Semon, A, Doron, I, Gao, IH, Putzel, GG, Kim, Y, Kabata, H, Artis, D, Fiers, WD, Ramer-Tait, AE & Iliev, ID 2018, ' Response to Fungal Dysbiosis by Gut-Resident CX3CR1 ⁺ Mononuclear Phagocytes Aggravates Allergic Airway Disease ', Cell Host and Microbe, vol. 24, no. 6, pp. 847-856.e4. https://doi.org/10.1016/j.chom.2018.11.003

Li, Xin ; Leonardi, Irina ; Semon, Alexa ; Doron, Itai ; Gao, Iris H. ; Putzel, Gregory Garbès ; Kim, Youngjun ; Kabata, Hiroki ; Artis, David ; Fiers, William D. ; Ramer-Tait, Amanda E. ; Iliev, Iliyan D. / Response to Fungal Dysbiosis by Gut-Resident CX3CR1 ⁺ Mononuclear Phagocytes Aggravates Allergic Airway Disease In: Cell Host and Microbe. 2018 ; Vol. 24, No. 6. pp. 847-856.e4.

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