Response to Fungal Dysbiosis by Gut-Resident CX3CR1 + Mononuclear Phagocytes Aggravates Allergic Airway Disease

Xin Li, Irina Leonardi, Alexa Semon, Itai Doron, Iris H. Gao, Gregory Garbès Putzel, Youngjun Kim, Hiroki Kabata, David Artis, William D. Fiers, Amanda E. Ramer-Tait, Iliyan D. Iliev

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

How mycobiota influence immunity in gut distal sites is not well understood. Li et al. developed protocols for gut-targeted depletion of phagocytes and mycobiota-free mice to investigate the influence of fungi on gut-lung crosstalk. They reveal that intestinal phagocytes sense fungal dysbiosis and mediate gut-lung-directed immunity to aggravate allergic airway disease.

Original languageEnglish (US)
Pages (from-to)847-856.e4
JournalCell Host and Microbe
Volume24
Issue number6
DOIs
StatePublished - Dec 12 2018

Keywords

  • CX3CR1 mononuclear phagocytes
  • fungi
  • gut-lung axis
  • mycobiome
  • mycobiota dysbiosis

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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