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Response to Letter to the Editor from Drs. van Kesteren, Pronk, Heusinkveld, Luijten and Hakkert concerning Yamada et al. (2021) : Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Crit. Rev. Toxicol. Vol. 51: 373-394. / Yamada, Tomoya; Cohen, Samuel M.; Lake, Brian G.In: Critical reviews in toxicology, Vol. 52, No. 5, 2022, p. 399-402.
Research output: Contribution to journal › Review article › peer-review
TY - JOUR
T1 - Response to Letter to the Editor from Drs. van Kesteren, Pronk, Heusinkveld, Luijten and Hakkert concerning Yamada et al. (2021)
T2 - Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Crit. Rev. Toxicol. Vol. 51: 373-394.
AU - Yamada, Tomoya
AU - Cohen, Samuel M.
AU - Lake, Brian G.
N1 - Funding Information: Dr. Tomoya Yamada is employed by Sumitomo Chemical Company, Ltd. Prof. Samuel M. Cohen and Prof. Brian G. Lake consult for Sumitomo Chemical Company, Ltd. regarding research on CAR activators as well as on other matters. The response was written as part of the authors’ normal employment, but the authors have sole responsibility for the writing and content of this response. The views presented in this response are those of the authors based on many years of research in the respective areas of investigations reported in this response. This work was supported by the Sumitomo Chemical Company, Ltd. ( https://www.sumitomo-chem.co.jp/eng-lish/company/ ). This company is interested in the human relevance of the CAR-mediated MOA for rodent liver tumor formation, because some company products (e.g. pesticides) have CAR activation activity in rodent liver. Some of the research on CAR activators produced by Sumitomo Chemical Company, Ltd. has been utilized by the company in regulatory submissions to provide MOA information for interpreting the relevance to humans of the liver tumors in rodents. None of the authors has appeared in any legal or regulatory proceedings related to the contents of this response. No potential conflict of interest was reported by the authors. Funding Information: The authors thank members of Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd. for their encouragement to write this response. All authors gave final approval and agreed to be accountable for all aspects of work in ensuring that questions relating to the accuracy or integrity of any part of the work are appropriately investigated and resolved. An additional review of the response for internal approval purposes was conducted by Kyoko Odawara, a Research Director of Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., and approved without any changes to what we had written.
PY - 2022
Y1 - 2022
UR - http://www.scopus.com/inward/record.url?scp=85136172224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85136172224&partnerID=8YFLogxK
U2 - 10.1080/10408444.2022.2101915
DO - 10.1080/10408444.2022.2101915
M3 - Review article
C2 - 35971811
AN - SCOPUS:85136172224
VL - 52
SP - 399
EP - 402
JO - Critical Reviews in Toxicology
JF - Critical Reviews in Toxicology
SN - 1040-8444
IS - 5