Responses of peripheral auditory neurons to two-tone stimuli during development: III. Rate facilitation

Janet L. Fitzakerley, Joann McGee, Edward J. Walsh

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations

    Abstract

    Approximately 25% of peripheral auditory neurons having low characteristic frequencies (CFs) and broad tuning, and recorded from immature animals, responded to two-tone stimuli with increases in discharge rate greater than predicted by linear summation of the responses to probe tones (facilitation), in contrast to the two-tone suppression observed in adult animals and in more sharply tuned immature neurons. Facilitation was not seen after 81 gestational days and was not observed when test tones produced a substantial increase in rate when presented alone. The fact that some neural responses were facilitated under conditions of two-tone stimulation during the final stages of cochlear differentiation provides additional evidence that signal transduction is fundamentally different in neonatal kittens than in adults. A linear model of basilar membrane mechanics coupled to nonlinear neural processes is proposed which can account for the production of facilitation.

    Original languageEnglish (US)
    Pages (from-to)162-167
    Number of pages6
    JournalHearing Research
    Volume77
    Issue number1-2
    DOIs
    StatePublished - Jun 15 1994

    Keywords

    • Auditory nerve
    • Cochlear nuclear complex
    • Development
    • Two-tone suppression

    ASJC Scopus subject areas

    • Sensory Systems

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