Responses of peripheral auditory neurons to two-tone stimuli during development: III. Rate facilitation

Janet L. Fitzakerley, Joann McGee, Edward J. Walsh

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Approximately 25% of peripheral auditory neurons having low characteristic frequencies (CFs) and broad tuning, and recorded from immature animals, responded to two-tone stimuli with increases in discharge rate greater than predicted by linear summation of the responses to probe tones (facilitation), in contrast to the two-tone suppression observed in adult animals and in more sharply tuned immature neurons. Facilitation was not seen after 81 gestational days and was not observed when test tones produced a substantial increase in rate when presented alone. The fact that some neural responses were facilitated under conditions of two-tone stimulation during the final stages of cochlear differentiation provides additional evidence that signal transduction is fundamentally different in neonatal kittens than in adults. A linear model of basilar membrane mechanics coupled to nonlinear neural processes is proposed which can account for the production of facilitation.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalHearing Research
Volume77
Issue number1-2
DOIs
StatePublished - Jun 15 1994

Keywords

  • Auditory nerve
  • Cochlear nuclear complex
  • Development
  • Two-tone suppression

ASJC Scopus subject areas

  • Sensory Systems

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