Responses of peripheral auditory neurons to two-tone stimuli during development: I. Correlation with frequency selectivity

Janet L. Fitzakerley, JoAnn McGee, Edward J. Walsh

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The responses of peripheral auditory neurons to two-tone stimuli were used to inferentially examine the nature of cochlear processing during development. Rate suppression was not seen in the youngest animals, and was first observed at 77 gestational days, in units exhibiting adultlike frequency selectivity. Suppression was highly correlated with the degree of tuning, and neurons were segregated into three classes based on these responses. Broadly tuned neurons (type IB) with low characteristic frequencies (CFs) did not exhibit suppression, and were observed early in postnatal life. Sharply tuned, but still immature neurons (type IS) exhibited suppression, but to a lesser degree than mature neurons (type M). One interpretation of these results is that basilar membrane mechanics are linear during the final stages of cochlear development, indicating that the immature signal transduction process is fundamentally different from that of adults.

Original languageEnglish (US)
Pages (from-to)135-149
Number of pages15
JournalHearing Research
Volume77
Issue number1-2
DOIs
StatePublished - Jun 15 1994

Keywords

  • Auditory nerve
  • Cochlear nuclear complex
  • Development
  • Two-tone suppression

ASJC Scopus subject areas

  • Sensory Systems

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