TY - JOUR
T1 - Restoration of circadian behavior by anterior hypothalamic grafts containing the suprachiasmatic nucleus
T2 - Graft/host interconnections
AU - Sollars, Patricia J.
AU - Pickard, Gary E.
PY - 1998
Y1 - 1998
N2 - Destruction of the hypothalamic suprachiasmatic nucleus (SCN) disrupts circadian behavior. Transplanting SeN tissue from fetal donors into SCN- lesioned recipients can restore circadian behavior to the arhythmic hosts. In the transplantation model employing fetal hamster donors and SCN-lesioned hamsters as hosts, the period of the restored circadian behavior is hamster- typical. However, when fetal rat anterior hypothalamic tissue containing the SeN is implanted into SCN-lesioned rats, the period of the restored circadian rhythm is only rarely typical of that of the intact rat. The use of an anterior hypothalamic heterograft model provides new approaches to donor specificity of restored circadian behavior and with the aid of species- specific markers, provides a means for assessing connectivity between the graft and the host. Using an antibody that stains rat and mouse neuronal tissue but not hamster neurons, it has been demonstrated that rat and mouse anterior hypothalamic heterografts containing the SeN send numerous processes into the host (hamster) neuropil surrounding the graft, consistent with graft efferents reported in other hypothalamic transplantation models in which graft and host tissue can be differentiated (i.e., Brattleboro rat and hypogonadal mouse). Moreover, SCN neurons within anterior hypothalamic grafts send an appropriately restricted set of efferent projections to the host brain which may participate in the functional recovery of circadian locomotor activity.
AB - Destruction of the hypothalamic suprachiasmatic nucleus (SCN) disrupts circadian behavior. Transplanting SeN tissue from fetal donors into SCN- lesioned recipients can restore circadian behavior to the arhythmic hosts. In the transplantation model employing fetal hamster donors and SCN-lesioned hamsters as hosts, the period of the restored circadian behavior is hamster- typical. However, when fetal rat anterior hypothalamic tissue containing the SeN is implanted into SCN-lesioned rats, the period of the restored circadian rhythm is only rarely typical of that of the intact rat. The use of an anterior hypothalamic heterograft model provides new approaches to donor specificity of restored circadian behavior and with the aid of species- specific markers, provides a means for assessing connectivity between the graft and the host. Using an antibody that stains rat and mouse neuronal tissue but not hamster neurons, it has been demonstrated that rat and mouse anterior hypothalamic heterografts containing the SeN send numerous processes into the host (hamster) neuropil surrounding the graft, consistent with graft efferents reported in other hypothalamic transplantation models in which graft and host tissue can be differentiated (i.e., Brattleboro rat and hypogonadal mouse). Moreover, SCN neurons within anterior hypothalamic grafts send an appropriately restricted set of efferent projections to the host brain which may participate in the functional recovery of circadian locomotor activity.
KW - Circadian rhythms
KW - Neural transplantation Heterografts
KW - Suprachiasmatic nucleus
UR - http://www.scopus.com/inward/record.url?scp=0031709184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031709184&partnerID=8YFLogxK
U2 - 10.3109/07420529808998705
DO - 10.3109/07420529808998705
M3 - Review article
C2 - 9787939
AN - SCOPUS:0031709184
SN - 0742-0528
VL - 15
SP - 513
EP - 533
JO - Chronobiology International
JF - Chronobiology International
IS - 5
ER -