Resveratrol and Cerebral Arterioles during Type 1 Diabetes

William G. Mayhan, Denise M. Arrick

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Chronic hyperglycemia is associated with type 1 diabetes, and produces damage to many organ systems (including the brain), is a major cause of morbidity and mortality, and is a major economic burden throughout the world. Investigators have suggested that the damaging effects of diabetes on peripheral organs appear to be related to an increase in oxidative stress. Alterations in the reactivity of large and small arteries may contribute to the progression of organ damage observed in diabetics. The brain and the blood vessels within it are also susceptible to the damaging effects of hyperglycemia-induced increases in oxidative stress. Impaired dilation of cerebral vessels due to an increase in oxidative stress may contribute to the pathogenesis of diabetes-induced complications of the brain, including cognitive impairment and stroke. Many naturally occurring compounds are capable of ameliorating oxidative stress in blood vessels, thus producing an increase in overall vascular health. We will focus on the positive influence of resveratrol on cerebral arterioles in type 1 diabetes. We suggest an important therapeutic potential for resveratrol in treating diabetes-induced cerebrovascular dysfunction, including cognitive impairment and stroke.

Original languageEnglish (US)
Title of host publicationDiabetes
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
PublisherElsevier Inc.
Pages191-199
Number of pages9
ISBN (Print)9780124058859
DOIs
StatePublished - Nov 2013
Externally publishedYes

Keywords

  • Adenosine 5'-diphosphate
  • Brain
  • Cerebral arterioles
  • ENOS
  • N-methyl-d-aspartic acid
  • Nitric oxide
  • Nitroglycerin
  • SOD1
  • SOD2
  • Superoxide anion

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Fingerprint Dive into the research topics of 'Resveratrol and Cerebral Arterioles during Type 1 Diabetes'. Together they form a unique fingerprint.

Cite this