Retention and transmission of active transcription memory from progenitor to progeny cells via ligand-modulated transcription factors: Elucidation of a concept by BIOPIT model

Sanjay Kumar, Mallampati Saradhi, Nagendra K. Chaturvedi, Rakesh K. Tyagi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Observations made in live cells have clearly demonstrated that agonist-activated steroid/nuclear receptors reorganize in the nucleoplasm into hundreds of discrete speckled structures commonly referred to as nuclear foci. Subsequent studies have shown that nuclear foci are formed only with agonist- and not with pure antagonist-bound receptors. Also, the other accessory components of transcriptional machinery co-localize in nuclear foci with the activated receptors, suggesting these to be active gene transcription sites. Recently, it has been observed that duringmitosis nuclear foci present in interphase of progenitor cells co-migrate with condensing chromatin and are inherited into the progeny cells. Ensuing events imply that as memory, the cells inherit only a biomolecular blueprint of transcription status over to next generations to express and sustain their characteristic proteome. Thus, cells achieve self-renewal via mitosis but not without ensuring that the characteristic proteome and traits are distinctively preserved during this transcription phase. This mechanism, although somewhat analogous to epigenetic marking, differs in Nature since transcription factors themselves execute this transmission. To uphold the mechanistic distinctions the phenomenon has been termed BIOPIT (biomolecular imprints offered to progeny for inheritance of traits). The BIOPIT model proposed herein attempts to explain how the disruption of BIOPIT markings by therapeutic anti-hormones or endocrine disruptors over prolonged periods may lead to eradication of cellular transcription memory with deleterious cellular consequences. It is anticipated that our model has the potential to explain the concerted actions and consequences of ligand-receptor interactions with the chromatin in the perspective of normal and aberrant physiological situations.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalCell Biology International
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Mitotic chromatin
  • Nuclear foci
  • Nuclear receptor (NR)
  • Transcription memory

ASJC Scopus subject areas

  • Cell Biology

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