Retinal stem cells

Carolina B. Del Debbio, Sowmya Parameswaran, Ani V. Das, Iqbal Ahmad

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The retina is a simple and an accessible model of the central nervous system that has been used to further our understanding of how the brain develops and functions. It holds similar promise for shedding light on why and how specific neuronal types degenerate, and devising stem cell-based approaches for treating neurodegenerative changes. Retinal stem cells generate all seven major retinal cell types, including Muller glia in an evolutionarily conserved temporal sequence. Here, we first describe the approaches to isolate and characterize retinal stem cells. Second, we discuss the signaling pathways implicated in their maintenance. Third, factors underlying the neuronal and glial differentiation of retinal stem cells are highlighted, and finally we discuss the recently identified stem cells properties of Muller glia in adult retina, which has an implication in retinal regeneration.

Original languageEnglish (US)
Title of host publicationNeural Development and Stem Cells
Subtitle of host publicationThird Edition
PublisherSpringer New York
Pages223-244
Number of pages22
ISBN (Electronic)9781461438014
ISBN (Print)9781461438007
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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