Retinoid metabolism during development of liver cirrhosis

Sathish Kumar Natarajan, Simmy Thomas, Anup Ramachandran, Anna B. Pulimood, Kunnissery A. Balasubramanian

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The changes in retinoid metabolism have been documented in liver cirrhosis. However, the dynamic alterations in levels of this vitamin between circulation and liver during development of the liver cirrhosis are not well understood. The aim of this study was to measure retinoids in the liver and circulation in parallel, during and after development of cirrhosis induced by carbon tetrachloride and thioacetamide. Retinoid levels were measured by HPLC. A decrease in retinaldehyde and total retinol, together with an increase in retinoic acid was evident in liver from both carbon tetrachloride or thioacetamide treated rats within a month after initiation of treatment. Activity of enzymes involved in retinoid metabolism such as retinaldehyde oxidase, retinaldehyde dehydrogenase, and retinaldehyde reductase were decreased in the liver. In parallel, levels of retinol and retinaldehyde in the serum were increased while retinoic acid was decreased. This study indicates that during development of cirrhosis, there is reciprocal transfer of retinoid metabolites between the circulation and the liver.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalArchives of Biochemistry and Biophysics
Issue number1-2
StatePublished - Nov 15 2005
Externally publishedYes


  • Metabolizing enzymes
  • Retinaldehyde
  • Retinoic acid
  • Retinol

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology


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