Retrograde transneuronal transport of Herpex simplex virus in the retina after injection in the superior colliculus, hypothalamus and optic chiasm

Robert B. Norgren; Michael N. Lehman

doi:10.1016/0006-8993(89)91644-2

Retrograde transneuronal transport of Herpex simplex virus in the retina after injection in the superior colliculus, hypothalamus and optic chiasm

Robert B. Norgren, Michael N. Lehman

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Immunocytochemistry was used to identify infected cells after injection of Herpes simplex virus (HSV) into the superior colliculus, hypothalamus and optic chiasm. Ganglion cells of the retina were labeled in a pattern consistent with known projections to retinorecipient nuclei. Cells of both inner and outer nuclear layer were labeled. If this represents retrograde transneuronal transport, then HSV may provide an important tool for studying the neuronal circuitry of the retina.

Original language	English (US)
Pages (from-to)	374-378
Number of pages	5
Journal	Brain Research
Volume	479
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(89)91644-2
State	Published - Feb 13 1989

Keywords

Hamster
Herpes simplex virus
Retina
Superior colliculus
Suprachiasmatic nucleus
Transneuronal labeling

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91644-2

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AB - Immunocytochemistry was used to identify infected cells after injection of Herpes simplex virus (HSV) into the superior colliculus, hypothalamus and optic chiasm. Ganglion cells of the retina were labeled in a pattern consistent with known projections to retinorecipient nuclei. Cells of both inner and outer nuclear layer were labeled. If this represents retrograde transneuronal transport, then HSV may provide an important tool for studying the neuronal circuitry of the retina.

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KW - Suprachiasmatic nucleus

KW - Transneuronal labeling

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