Retrograde transneuronal transport of Herpex simplex virus in the retina after injection in the superior colliculus, hypothalamus and optic chiasm

Robert B. Norgren, Michael N. Lehman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Immunocytochemistry was used to identify infected cells after injection of Herpes simplex virus (HSV) into the superior colliculus, hypothalamus and optic chiasm. Ganglion cells of the retina were labeled in a pattern consistent with known projections to retinorecipient nuclei. Cells of both inner and outer nuclear layer were labeled. If this represents retrograde transneuronal transport, then HSV may provide an important tool for studying the neuronal circuitry of the retina.

Original languageEnglish (US)
Pages (from-to)374-378
Number of pages5
JournalBrain Research
Volume479
Issue number2
DOIs
StatePublished - Feb 13 1989

Keywords

  • Hamster
  • Herpes simplex virus
  • Retina
  • Superior colliculus
  • Suprachiasmatic nucleus
  • Transneuronal labeling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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