TY - JOUR
T1 - Reversal of the Sodium Chloride Aversion of Fischer 344 Rats by Chorda Tympani Nerve Transection
AU - Sollars, Suzanne I.
AU - Sollars, Patricia J.
AU - Bernstein, Ilene L.
PY - 1991/8
Y1 - 1991/8
N2 - Fischer 344 (F344) rats are atypical in their lack of preference for any concentration of NaCl solution over water. It was hypothesized that abnormal signals mediated by the chorda tympani nerve (CT) could be causally involved in NaCl avoidance by F344 rats. This study assessed whether CT transection would normalize the salt preference of F344 rats. Preference for NaCl solutions (0.6%, 0.8%, and 1.0%) versus water was assessed using two-bottle preference tests. At all concentrations tested, CT-transected animals preferred NaCl solutions to water. This preference differed dramatically from the avoidance of these solutions by controls. These findings are striking, particularly because CT transections have generally failed to significantly affect NaCl preference in other rat strains. The results are consistent with the hypothesis that in F344 rats the avoidance of the taste of NaCl stems from input mediated by the CT.
AB - Fischer 344 (F344) rats are atypical in their lack of preference for any concentration of NaCl solution over water. It was hypothesized that abnormal signals mediated by the chorda tympani nerve (CT) could be causally involved in NaCl avoidance by F344 rats. This study assessed whether CT transection would normalize the salt preference of F344 rats. Preference for NaCl solutions (0.6%, 0.8%, and 1.0%) versus water was assessed using two-bottle preference tests. At all concentrations tested, CT-transected animals preferred NaCl solutions to water. This preference differed dramatically from the avoidance of these solutions by controls. These findings are striking, particularly because CT transections have generally failed to significantly affect NaCl preference in other rat strains. The results are consistent with the hypothesis that in F344 rats the avoidance of the taste of NaCl stems from input mediated by the CT.
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U2 - 10.1037/0735-7044.105.4.603
DO - 10.1037/0735-7044.105.4.603
M3 - Article
C2 - 1930728
AN - SCOPUS:0025991999
SN - 0735-7044
VL - 105
SP - 603
EP - 605
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 4
ER -