REVERSIBILITY OF LYMPHOMAS AND LYMPHOPROLIFERATIVE LESIONS DEVELOPING UNDER CYCLOSPORIN-STEROID THERAPY

T. E. Starzl, K. A. Porter, S. Iwatsuki, J. T. Rosenthal, B. W. Shaw, R. W. Atchison, M. A. Nalesnik, M. Ho, B. P. Griffith, T. R. Hakala, R. L. Hardesty, R. Jaffe, H. T. Bahnson

Research output: Contribution to journalArticle

965 Scopus citations

Abstract

Post-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts. Reduction or discontinuance of immunosuppression caused regression of the lesions, often without subsequent rejection of the grafts. Chemotherapy and irradiation were not valuable. The findings may influence policies about treating other kinds of post-transplantation neoplasms.

Original languageEnglish (US)
Pages (from-to)583-587
Number of pages5
JournalThe Lancet
Volume323
Issue number8377
DOIs
StatePublished - Mar 17 1984

ASJC Scopus subject areas

  • Medicine(all)

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