Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Swagat Sharma, Corey R. Hopkins

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Transient receptor potential canonical (TRPC) channels are highly homologous, nonselective cation channels that form many homo- and heterotetrameric channels. These channels are highly abundant in the brain and kidney and have been implicated in numerous diseases, such as depression, addiction, and chronic kidney disease, among others. Historically, there have been very few selective modulators of the TRPC family in order to fully understand their role in disease despite their physiological significance. However, that has changed recently and there has been a significant increase in interest in this family of channels which has led to the emergence of selective tool compounds, and even preclinical drug candidates, over the past few years. This review will cover these new advancements in the discovery of TRPC modulators and the emergence of newly reported structural information which will undoubtedly lead to even greater advancements.

Original languageEnglish (US)
Pages (from-to)7589-7602
Number of pages14
JournalJournal of Medicinal Chemistry
Issue number17
StatePublished - Sep 12 2019

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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