Rhabdomyolysis and myoglobinemia in neonates

J. W. Kasik, M. P. Leuschen, D. L. Bolam, R. M. Nelson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Serial myoglobin determinations were made in 20 neonates during the first week of life to determine whether birth asphyxia results in ischemic damage to muscle with the subsequent pathologic release of myoglobin. Serum myoglobin values were significantly elevated in asphyxiated infants compared with control infants. High myoglobin values correlated with a longer duration of oliguria in the neonatal intensive care unit population. The value of urine dipstick testing for myoglobinuria screening was also evaluated. Infants with elevated myoglobin values were more likely to have a strongly positive urine dipstick for occult blood in the first 48 hours of life. These data suggest that ischemic damage to muscle with pathologic release of myoglobin occurs in the neonatal period and that urine dipstick testing provides a reasonable screening examination for myoglobinuria.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalPediatrics
Volume76
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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