Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection

Nicole Espy, Unai Pérez-Sautu, Eva Ramírez De Arellano, Anabel Negredo, Michael R. Wiley, Sina Bavari, Marta Díaz Menendez, María Paz Sánchez-Seco, Gustavo Palacios

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.

Original languageEnglish (US)
Pages (from-to)1952-1956
Number of pages5
JournalJournal of Infectious Diseases
Volume217
Issue number12
DOIs
StatePublished - May 25 2018

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Keywords

  • Crimean-Congo hemorrhagic fever virus
  • ribavirin
  • viral genomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Espy, N., Pérez-Sautu, U., De Arellano, E. R., Negredo, A., Wiley, M. R., Bavari, S., Menendez, M. D., Sánchez-Seco, M. P., & Palacios, G. (2018). Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection. Journal of Infectious Diseases, 217(12), 1952-1956. https://doi.org/10.1093/infdis/jiy163