Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection

Nicole Espy; Unai Pérez-Sautu; Eva Ramírez De Arellano; Anabel Negredo; Michael R. Wiley; Sina Bavari; Marta Díaz Menendez; María Paz Sánchez-Seco; Gustavo Palacios

doi:10.1093/infdis/jiy163

Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection

Nicole Espy, Unai Pérez-Sautu, Eva Ramírez De Arellano, Anabel Negredo, Michael R. Wiley, Sina Bavari, Marta Díaz Menendez, María Paz Sánchez-Seco, Gustavo Palacios

Environmental, Agricultural & Occupational Health Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.

Original language	English (US)
Pages (from-to)	1952-1956
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	217
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiy163
State	Published - May 25 2018

Keywords

Crimean-Congo hemorrhagic fever virus
ribavirin
viral genomics

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jiy163

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Espy, N., Pérez-Sautu, U., De Arellano, E. R., Negredo, A., Wiley, M. R., Bavari, S., Menendez, M. D., Sánchez-Seco, M. P., & Palacios, G. (2018). Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection. Journal of Infectious Diseases, 217(12), 1952-1956. https://doi.org/10.1093/infdis/jiy163

Espy, N, Pérez-Sautu, U, De Arellano, ER, Negredo, A, Wiley, MR, Bavari, S, Menendez, MD, Sánchez-Seco, MP & Palacios, G 2018, 'Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection', Journal of Infectious Diseases, vol. 217, no. 12, pp. 1952-1956. https://doi.org/10.1093/infdis/jiy163

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abstract = "The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.",

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Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection

Abstract

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