TY - JOUR
T1 - Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection
AU - Espy, Nicole
AU - Pérez-Sautu, Unai
AU - De Arellano, Eva Ramírez
AU - Negredo, Anabel
AU - Wiley, Michael R.
AU - Bavari, Sina
AU - Menendez, Marta Díaz
AU - Sánchez-Seco, María Paz
AU - Palacios, Gustavo
N1 - Funding Information:
Financial support. This work was supported by Red de Investigación Cooperativa en Enfermedades Tropicales (grant RD12/0018/0023); the Efficient Response to Highly Dangerous and Emerging Pathogens at the European Union (EU) Level, a joint action funded under the third EU Health Program (677066); and the Joint Science and Technology Office for Chemical and Biological Defense, Defense Threat Reduction Agency (plan CB10246).
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/5/25
Y1 - 2018/5/25
N2 - The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.
AB - The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.
KW - Crimean-Congo hemorrhagic fever virus
KW - ribavirin
KW - viral genomics
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U2 - 10.1093/infdis/jiy163
DO - 10.1093/infdis/jiy163
M3 - Article
C2 - 29584885
AN - SCOPUS:85048145857
VL - 217
SP - 1952
EP - 1956
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 12
ER -