Right ventricular phenotypic characteristics in subjects with primary pulmonary hypertension or idiopathic dilated cardiomyopathy

Robert A. Quaife, David Lynch, David B. Badesch, Norbert F. Voelkel, Brian D. Lowes, Alastair D. Robertson, Michael R. Bristow

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Studies of animal models and human subjects with cardiomyopathies suggest that cardiac myocyte and ventricular chamber remodeling show distinct phenotypic characteristics that may be dependent on specific signaling pathways. Methods and Results: In this study, we characterize right ventricular (RV) chamber size, end-diastolic thickness, myocardial mass, and ejection fraction (EF) in human subjects with chronic heart failure from primary pulmonary hypertension (PPH; n = 10) and idiopathic dilated cardiomyopathy (IDC; n = 10). Subjects underwent gated cardiac magnetic resonance imaging (MRI), and the RVs were phenotypically classified based on the presence or absence of hypertrophy (increased mass), systolic dysfunction (reduced EF), and degree of wall thickness (concentric v eccentric pattern of hypertrophy). Within this schema, five abnormal phenotypes could be identified. In PPH subjects, in whom the RV is subjected to the uniform insult of chronic pressure overload, four different abnormal phenotypes were identified. Conclusions: These data indicate that distinct structural/functional ventricular chamber phenotypes may be classified by MRI, and that a uniform insult can result in multiple RV phenotypes.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalJournal of Cardiac Failure
Volume5
Issue number1
DOIs
StatePublished - Mar 1999

Keywords

  • Classification
  • IDC
  • PPH
  • RV

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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