Abstract
In this study, two specimens of a parosteal osteosarcoma, a rare primary bone neoplasm comprising only 3-6% of all osteosarcomas, were cytogenetically analyzed utilizing standard techniques. In contrast to the complex karyotypes previously reported in osteosarcoma, this particular histologic subtype was characterized by a single chromosomal aberration, a ring chromosome. Ring chromosomes have been described as characteristic for two other low-grade malignant mesenchymal neoplasms, well-differentiated liposarcoma and dermatofibrosarcoma protuberans. We propose that the observation of a ring chromosome in osteosarcoma also correlates with a low-grade malignant potential.
Original language | English (US) |
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Pages (from-to) | 50-52 |
Number of pages | 3 |
Journal | Cancer genetics and cytogenetics |
Volume | 62 |
Issue number | 1 |
DOIs | |
State | Published - Aug 1992 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research