Ring chromosome in parosteal osteosarcoma. Clinical and diagnostic significance

Jane F. Sinovic, Julia A. Bridge, James R. Neff

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


In this study, two specimens of a parosteal osteosarcoma, a rare primary bone neoplasm comprising only 3-6% of all osteosarcomas, were cytogenetically analyzed utilizing standard techniques. In contrast to the complex karyotypes previously reported in osteosarcoma, this particular histologic subtype was characterized by a single chromosomal aberration, a ring chromosome. Ring chromosomes have been described as characteristic for two other low-grade malignant mesenchymal neoplasms, well-differentiated liposarcoma and dermatofibrosarcoma protuberans. We propose that the observation of a ring chromosome in osteosarcoma also correlates with a low-grade malignant potential.

Original languageEnglish (US)
Pages (from-to)50-52
Number of pages3
JournalCancer genetics and cytogenetics
Issue number1
StatePublished - Aug 1992

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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