Ring chromosome in parosteal osteosarcoma. Clinical and diagnostic significance

Jane F. Sinovic; Julia A. Bridge; James R. Neff

doi:10.1016/0165-4608(92)90038-A

Ring chromosome in parosteal osteosarcoma. Clinical and diagnostic significance

Jane F. Sinovic, Julia A. Bridge, James R. Neff

Pathology & Microbiology

Research output: Contribution to journal › Article

40 Scopus citations

Abstract

In this study, two specimens of a parosteal osteosarcoma, a rare primary bone neoplasm comprising only 3-6% of all osteosarcomas, were cytogenetically analyzed utilizing standard techniques. In contrast to the complex karyotypes previously reported in osteosarcoma, this particular histologic subtype was characterized by a single chromosomal aberration, a ring chromosome. Ring chromosomes have been described as characteristic for two other low-grade malignant mesenchymal neoplasms, well-differentiated liposarcoma and dermatofibrosarcoma protuberans. We propose that the observation of a ring chromosome in osteosarcoma also correlates with a low-grade malignant potential.

Original language	English (US)
Pages (from-to)	50-52
Number of pages	3
Journal	Cancer genetics and cytogenetics
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(92)90038-A
State	Published - Aug 1992

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ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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Sinovic, J. F., Bridge, J. A., & Neff, J. R. (1992). Ring chromosome in parosteal osteosarcoma. Clinical and diagnostic significance. Cancer genetics and cytogenetics, 62(1), 50-52. https://doi.org/10.1016/0165-4608(92)90038-A

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10.1016/0165-4608(92)90038-A