Risk of new onset diabetes mellitus in patients with asthma or COPD taking inhaled corticosteroids

P. M. O'Byrne, S. Rennard, H. Gerstein, F. Radner, S. Peterson, B. Lindberg, L. G. Carlsson, D. D. Sin

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Background: A recent case-controlled study reported an increased risk of diabetes mellitus in patients treated with inhaled corticosteroids for asthma or COPD, versus age-matched controls. Objective: The purpose of the current study was to evaluate whether there was an increased risk of new onset diabetes mellitus or hyperglycaemia among patients with asthma or COPD treated with inhaled corticosteroids. Methods: A retrospective analysis evaluated all double-blind, placebo-controlled, trials in patients ≥4 years of age involving budesonide or budesonide/formoterol in asthma (26 trials; budesonide: n = 9067; placebo: n = 5926), and in COPD (8 trials; budesonide: n = 4616; non-ICS: n = 3643). A secondary dataset evaluated all double-blind, controlled trials in asthma involving the use of inhaled corticosteroids (60 trials; budesonide: n = 33,496; fluticasone: n = 2773). Results: In the primary asthma dataset, the occurrence of diabetes mellitus/hyperglycaemia adverse events (AEs) was 0.13% for budesonide and 0.13% for placebo (HR 0.98 [95% CI: 0.38-2.50], p = 0.96) and serious adverse events (SAEs) was 0% for budesonide and 0.05% for placebo. In the secondary dataset, the occurrence of diabetes/hyperglycaemia as AE and SAE was 0.19% and 0.03%, respectively. In the COPD dataset, the occurrence of diabetes mellitus/hyperglycaemia AEs was 1.3% for budesonide and 1.2% for non-ICS (HR 0.99 [95% CI: 0.67-1.46], p = 0.96) and SAEs was 0.1% for budesonide and 0.03% for non-ICS. Conclusion and clinical relevance: Treatment with inhaled corticosteroids in patients with asthma or COPD was not associated with increased risk of new onset diabetes mellitus or hyperglycaemia.

Original languageEnglish (US)
Pages (from-to)1487-1493
Number of pages7
JournalRespiratory Medicine
Volume106
Issue number11
DOIs
StatePublished - Nov 2012

Keywords

  • Budesonide
  • Hyperglycaemia
  • Side-effects

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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