Rituximab pharmacokinetics in children and adolescents with de novo intermediate and advanced mature B-cell lymphoma/leukaemia: A Children's Oncology Group report

Matthew J. Barth; Stanton Goldman; Lynette Smith; Sherrie Perkins; Bruce Shiramizu; Thomas G. Gross; Lauren Harrison; Warren Sanger; Mark B. Geyer; Lisa Giulino-Roth; Mitchell S. Cairo

doi:10.1111/bjh.12434

Rituximab pharmacokinetics in children and adolescents with de novo intermediate and advanced mature B-cell lymphoma/leukaemia: A Children's Oncology Group report

Matthew J. Barth, Stanton Goldman, Lynette Smith, Sherrie Perkins, Bruce Shiramizu, Thomas G. Gross, Lauren Harrison, Warren Sanger, Mark B. Geyer, Lisa Giulino-Roth, Mitchell S. Cairo

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The ANHL01P1 trial was undertaken to determine pharmacokinetics and safety following the addition of rituximab to French-American-British/Lymphome Malins de Burkitt (FAB/LMB96) chemotherapy in 41 children and adolescents with Stage III/IV mature B-cell lymphoma/leukaemia. Patients received rituximab (375 mg/m²) days -2 and 0 of two induction cycles and day 0 of two consolidation cycles. Highest peak levels were achieved following the second dose of each induction cycle [299 ± 19 and 384 ± 25 μg/ml (Group-B); 245 ± 31 and 321 ± 32 μg/ml (Group-C)] with sustained troughs and t1/2 of 26-29 d. Rituximab can be safely added to FAB chemotherapy with high early rituximab peak/trough levels and a long t1/2.

Original language	English (US)
Pages (from-to)	678-683
Number of pages	6
Journal	British Journal of Haematology
Volume	162
Issue number	5
DOIs	https://doi.org/10.1111/bjh.12434
State	Published - Sep 2013

Keywords

CD20
Non-Hodgkin lymphoma
Pediatric
Pharmacokinetics
Rituximab

ASJC Scopus subject areas

Hematology

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10.1111/bjh.12434

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Barth, M. J., Goldman, S., Smith, L., Perkins, S., Shiramizu, B., Gross, T. G., Harrison, L., Sanger, W., Geyer, M. B., Giulino-Roth, L., & Cairo, M. S. (2013). Rituximab pharmacokinetics in children and adolescents with de novo intermediate and advanced mature B-cell lymphoma/leukaemia: A Children's Oncology Group report. British Journal of Haematology, 162(5), 678-683. https://doi.org/10.1111/bjh.12434

Barth, MJ, Goldman, S, Smith, L, Perkins, S, Shiramizu, B, Gross, TG, Harrison, L, Sanger, W, Geyer, MB, Giulino-Roth, L & Cairo, MS 2013, 'Rituximab pharmacokinetics in children and adolescents with de novo intermediate and advanced mature B-cell lymphoma/leukaemia: A Children's Oncology Group report', British Journal of Haematology, vol. 162, no. 5, pp. 678-683. https://doi.org/10.1111/bjh.12434

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abstract = "The ANHL01P1 trial was undertaken to determine pharmacokinetics and safety following the addition of rituximab to French-American-British/Lymphome Malins de Burkitt (FAB/LMB96) chemotherapy in 41 children and adolescents with Stage III/IV mature B-cell lymphoma/leukaemia. Patients received rituximab (375 mg/m2) days -2 and 0 of two induction cycles and day 0 of two consolidation cycles. Highest peak levels were achieved following the second dose of each induction cycle [299 ± 19 and 384 ± 25 μg/ml (Group-B); 245 ± 31 and 321 ± 32 μg/ml (Group-C)] with sustained troughs and t1/2 of 26-29 d. Rituximab can be safely added to FAB chemotherapy with high early rituximab peak/trough levels and a long t1/2.",

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AU - Shiramizu, Bruce

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Rituximab pharmacokinetics in children and adolescents with de novo intermediate and advanced mature B-cell lymphoma/leukaemia: A Children's Oncology Group report

Abstract

Keywords

ASJC Scopus subject areas

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