Rodent bladder tumors do not always predict for humans

Samuel M. Cohen, Terence A. Lawson

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Dr. David Clayson, 20 years ago, suggested that chemicals which lead to the formation of calculi in rodents might pose an artifact with respect to extrapolation to potential carcinogenic risk to humans. We reviewed what has been learned about the role of calculi in urinary bladder carcinogenesis in the ensuing 20 years, along with several examples. Formation of microcrystalluria and amorphous precipitate also poses problems in interpretation and examples are described. The chemicals producing these solid urinary materials are non-genotoxic, with marked increase in cell proliferation being the mode of action by which they are able to produce cancer in long-term rodent bioassays.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalCancer Letters
Volume93
Issue number1
DOIs
StatePublished - Jun 29 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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