Abstract
Cellular mechanisms which account for disruption of the blood-brain barrier during acute hypertension are not clear. The goal of this study was to determine the role of synthesis/release of bradykinin to activate B2 receptors in disruption of the blood-brain barrier during acute hypertension. Permeability of the blood-brain barrier was quantitated by clearance of fluorescent-labeled dextran before and during phenylephrine-induced acute hypertension in rats treated with vehicle and Hoe-140 (0.1 μM). Phenylephrine infusion increased arterial pressure, arteriolar diameter and clearance of fluorescent dextran by a similar magnitude in both groups. These findings suggest that disruption of the blood-brain barrier during acute hypertension is not related to the synthesis/release of bradykinin to activate B2 receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 337-341 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 738 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 4 1996 |
Keywords
- FITC-dextran
- Hoe-140
- brain
- cerebral microcirculation
- cerebral venules
- rat
- vascular permeability
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology