Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

R. Kadri; J. Bacharouch; K. Elkhoury; G. Ben Messaoud; C. Kahn; S. Desobry; M. Linder; A. Tamayol; G. Francius; J. F. Mano; L. Sánchez-González; E. Arab-Tehrany

doi:10.1016/j.mtbio.2020.100046

Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

R. Kadri, J. Bacharouch, K. Elkhoury, G. Ben Messaoud, C. Kahn, S. Desobry, M. Linder, A. Tamayol, G. Francius, J. F. Mano, L. Sánchez-González, E. Arab-Tehrany

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.

Original language	English (US)
Article number	100046
Journal	Materials Today Bio
Volume	6
DOIs	https://doi.org/10.1016/j.mtbio.2020.100046
State	Published - Mar 2020

Keywords

Alginate
GelMA
IPN hydrogels
Liposomes
Nanofunctionalization

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Biomedical Engineering
Molecular Biology
Cell Biology

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title = "Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels",

abstract = "Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.",

keywords = "Alginate, GelMA, IPN hydrogels, Liposomes, Nanofunctionalization",

author = "R. Kadri and J. Bacharouch and K. Elkhoury and {Ben Messaoud}, G. and C. Kahn and S. Desobry and M. Linder and A. Tamayol and G. Francius and Mano, {J. F.} and L. S{\'a}nchez-Gonz{\'a}lez and E. Arab-Tehrany",

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doi = "10.1016/j.mtbio.2020.100046",

language = "English (US)",

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journal = "Materials Today Bio",

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AU - Kadri, R.

AU - Bacharouch, J.

AU - Elkhoury, K.

AU - Ben Messaoud, G.

AU - Kahn, C.

AU - Desobry, S.

AU - Linder, M.

AU - Tamayol, A.

AU - Francius, G.

AU - Mano, J. F.

AU - Sánchez-González, L.

AU - Arab-Tehrany, E.

PY - 2020/3

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AB - Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.

KW - Alginate

KW - GelMA

KW - IPN hydrogels

KW - Liposomes

KW - Nanofunctionalization

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Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

Abstract

Keywords

ASJC Scopus subject areas

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