Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

R. Kadri, J. Bacharouch, K. Elkhoury, G. Ben Messaoud, C. Kahn, S. Desobry, M. Linder, A. Tamayol, G. Francius, J. F. Mano, L. Sánchez-González, E. Arab-Tehrany

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte ​growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.

Original languageEnglish (US)
Article number100046
JournalMaterials Today Bio
Volume6
DOIs
StatePublished - Mar 2020

Keywords

  • Alginate
  • GelMA
  • IPN hydrogels
  • Liposomes
  • Nanofunctionalization

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Cell Biology
  • Molecular Biology
  • Bioengineering
  • Biotechnology

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    Kadri, R., Bacharouch, J., Elkhoury, K., Ben Messaoud, G., Kahn, C., Desobry, S., Linder, M., Tamayol, A., Francius, G., Mano, J. F., Sánchez-González, L., & Arab-Tehrany, E. (2020). Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels. Materials Today Bio, 6, [100046]. https://doi.org/10.1016/j.mtbio.2020.100046