Role of brachytherapy in the management of the skull base meningioma treatment of skull base meningiomas

Pradeep P. Kumar, Hon‐Wei ‐W Syh, Wei‐Kom ‐K Chu, Michael A. Reeves, Angelo A. Patil

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background. The treatment of primary and recurrent skull base meningiomas presents a formidable surgical problem. Methods. Fifteen patients with primary and recurrent skull base meningiomas were treated by means of interstitial irradiation with iodine 125 (125I) seed implantation. The physical characteristics of 125I enabled the authors to administer a minimum tumor dose ranging from 100 to 500 Gy at a low dose rate of 0.05–0.25 Gy per hour. Results. All 15 patients are alive at a median follow‐up of 29 months. Of the 15 patients, 2 with calcification and 2 without calcification achieved only partial responses. The remaining 11 patients achieved a complete response. No early or late complications were observed. Conclusions. From these data, the authors conclude that interstitial irradiation with 125I seeds is an effective, safe, and simple method in the treatment of both recurrent and primary skull base meningiomas.

Original languageEnglish (US)
Pages (from-to)3726-3731
Number of pages6
JournalCancer
Volume71
Issue number11
DOIs
StatePublished - Jun 1 1993

Keywords

  • iodine 125 interstitial irradiation
  • low‐dose‐rate iodine 125 brachytherapy
  • nonsurgical management of meningiomas
  • skull base meningiomas

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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