Role of cell proliferation in regenerative and neoplastic disease

Samuel M. Cohen

doi:10.1016/0378-4274(95)03542-7

Role of cell proliferation in regenerative and neoplastic disease

Samuel M. Cohen

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

DNA replication does not have 100% fidelity. Consequently, a chemical can increase the risk of cancer either by directly damaging DNA (genotoxic) or by increasing the number of cell replications, or both. Increased cell proliferation can be produced by increasing cell births (by direct mitogenesis or regeneration following toxicity), or decreasing cell deaths (by inhibiting apoptosis or differentiation). Cell proliferation can affect the dose-response curve for genotoxic carcinogens and is the basis for carcinogenicity by nongenotoxic agents. Bladder carcinogens will be used to illustrate these mechanisms, and their implications with respect to human risk assessment will be presented.

Original language	English (US)
Pages (from-to)	15-21
Number of pages	7
Journal	Toxicology Letters
Volume	82-83
Issue number	C
DOIs	https://doi.org/10.1016/0378-4274(95)03542-7
State	Published - Dec 1995

Keywords

Acetylaminofluorene
Bladder carcinogenesis
Calculi
Cell proliferation
Sodium saccharin

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(95)03542-7

Cite this

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title = "Role of cell proliferation in regenerative and neoplastic disease",

abstract = "DNA replication does not have 100% fidelity. Consequently, a chemical can increase the risk of cancer either by directly damaging DNA (genotoxic) or by increasing the number of cell replications, or both. Increased cell proliferation can be produced by increasing cell births (by direct mitogenesis or regeneration following toxicity), or decreasing cell deaths (by inhibiting apoptosis or differentiation). Cell proliferation can affect the dose-response curve for genotoxic carcinogens and is the basis for carcinogenicity by nongenotoxic agents. Bladder carcinogens will be used to illustrate these mechanisms, and their implications with respect to human risk assessment will be presented.",

keywords = "Acetylaminofluorene, Bladder carcinogenesis, Calculi, Cell proliferation, Sodium saccharin",

author = "Cohen, {Samuel M.}",

note = "Funding Information: I gratefully acknowledge the assistance of Ginni Philbrick with the production of this manuscript.T he research performed in my laboratory is currently supported by a grant from the National Cancer Institute (CA32513), a grant from the International Life Sciences Institute-NA, and by funding from Bayer Corp. and Sumitomo Chemical Company.",

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doi = "10.1016/0378-4274(95)03542-7",

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T1 - Role of cell proliferation in regenerative and neoplastic disease

AU - Cohen, Samuel M.

N1 - Funding Information: I gratefully acknowledge the assistance of Ginni Philbrick with the production of this manuscript.T he research performed in my laboratory is currently supported by a grant from the National Cancer Institute (CA32513), a grant from the International Life Sciences Institute-NA, and by funding from Bayer Corp. and Sumitomo Chemical Company.

PY - 1995/12

Y1 - 1995/12

N2 - DNA replication does not have 100% fidelity. Consequently, a chemical can increase the risk of cancer either by directly damaging DNA (genotoxic) or by increasing the number of cell replications, or both. Increased cell proliferation can be produced by increasing cell births (by direct mitogenesis or regeneration following toxicity), or decreasing cell deaths (by inhibiting apoptosis or differentiation). Cell proliferation can affect the dose-response curve for genotoxic carcinogens and is the basis for carcinogenicity by nongenotoxic agents. Bladder carcinogens will be used to illustrate these mechanisms, and their implications with respect to human risk assessment will be presented.

AB - DNA replication does not have 100% fidelity. Consequently, a chemical can increase the risk of cancer either by directly damaging DNA (genotoxic) or by increasing the number of cell replications, or both. Increased cell proliferation can be produced by increasing cell births (by direct mitogenesis or regeneration following toxicity), or decreasing cell deaths (by inhibiting apoptosis or differentiation). Cell proliferation can affect the dose-response curve for genotoxic carcinogens and is the basis for carcinogenicity by nongenotoxic agents. Bladder carcinogens will be used to illustrate these mechanisms, and their implications with respect to human risk assessment will be presented.

KW - Acetylaminofluorene

KW - Bladder carcinogenesis

KW - Calculi

KW - Cell proliferation

KW - Sodium saccharin

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JF - Toxicology Letters

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Role of cell proliferation in regenerative and neoplastic disease

Abstract

Keywords

ASJC Scopus subject areas

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