TY - JOUR
T1 - Role of extracellular vesicles in substance abuse and HIV-related neurological pathologies
AU - Odegaard, Katherine E.
AU - Chand, Subhash
AU - Wheeler, Sydney
AU - Tiwari, Sneham
AU - Flores, Adrian
AU - Hernandez, Jordan
AU - Savine, Mason
AU - Gowen, Austin
AU - Pendyala, Gurudutt
AU - Yelamanchili, Sowmya V.
N1 - Funding Information:
Funding: This research was funded by NIDA grants R21DA046855 and R01DA042379 awarded to S.V.Y., R21DA049577 and R21DA046284 to G.P. and R01DA046852 to G.P. and S.V.Y.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/9/2
Y1 - 2020/9/2
N2 - Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.
AB - Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.
KW - Alcohol
KW - CNS disease
KW - Cocaine
KW - Drugs of abuse
KW - Extracellular vesicles (EV)
KW - HIV
KW - Methamphetamine (METH)
KW - MicroRNA (miRNA)
KW - Nicotine
KW - Opioids
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U2 - 10.3390/ijms21186765
DO - 10.3390/ijms21186765
M3 - Review article
C2 - 32942668
AN - SCOPUS:85090994671
SN - 1661-6596
VL - 21
SP - 1
EP - 22
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 18
M1 - 6765
ER -