Role of HER-2/neu overexpression and clinical features at presentation as predictive factors in meningiomas

Anil Potti, Amit Panwalkar, Eric Langness, Kaley Sholes, Ketki Tendulkar, Siddarth Chittajalu, Michael Koch

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Prediction of outcome in patients with meningiomas remains a significant problem to date. We have evaluated the role of symptoms at presentation and overexpression of her-2/neu overexpression as independent prognostic factors in meningiomas. In a retrospective study on patients with biopsy-proven diagnosis of meningioma, her-2/neu overexpression was evaluated using immunohistochemistry (IHC) performed on paraffin-embedded specimens. An IHC score of ≥2+ was considered positive for overexpression. Two hundred thirty-seven patients thus identified between January 1986 and December 1999 included 149 females and 88 males, with a mean age of 63.44 years. Survival was estimated using the Kaplan-Meier method. Incidence of meningiomas in females (62.8%) was significantly greater than in males. Focal neurodeficits, headache, and seizures (39.66%) were the most common presenting complaints and were not related to tumor behavior/outcome. Syncope at presentation was associated with a decreased survival, but this symptom constituted only 2.53% of the total, so reliable conclusions could not be drawn. Only 6 (2.53%) specimens revealed HER-2/neu overexpression by IHC. HER-2/neu overexpression is not a predictor of tumor behavior and has no role as a prognostic factor in meningiomas. Syncope as the clinical presentation at diagnosis may predict a poor outcome, but needs further investigation.

Original languageEnglish (US)
Pages (from-to)452-456
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume27
Issue number5
DOIs
StatePublished - Oct 2004

Keywords

  • Her-2/neu overexpression
  • Meningioma
  • Predictive factors
  • Symptoms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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