Role of miR-181 family in regulating vascular inflammation and immunity

Xinghui Sun, Alan Sit, Mark W. Feinberg

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

The microRNA family, miR-181, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Accumulating evidence supports a central role for the miR-181 family in vascular inflammation by controlling critical signaling pathways, such as downstream NF-κB signaling, and targets relevant to endothelial cell activation and immune cell homeostasis. This review examines the current knowledge of the miR-181 family's role in key cell types that critically control cardiovascular inflammation under pathological and physiological stimuli.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalTrends in Cardiovascular Medicine
Volume24
Issue number3
DOIs
StatePublished - Apr 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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