TY - JOUR
T1 - Role of miR-181 family in regulating vascular inflammation and immunity
AU - Sun, Xinghui
AU - Sit, Alan
AU - Feinberg, Mark W.
N1 - Funding Information:
This work was supported by the National Institutes of Health (HL091076, HL115141, and HL117994 to M.W.F.), a Watkins Cardiovascular Medicine Discovery Award (to M.W.F.), and a Jonathan Levy Research Fund (to M.W.F.).
PY - 2014/4
Y1 - 2014/4
N2 - The microRNA family, miR-181, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Accumulating evidence supports a central role for the miR-181 family in vascular inflammation by controlling critical signaling pathways, such as downstream NF-κB signaling, and targets relevant to endothelial cell activation and immune cell homeostasis. This review examines the current knowledge of the miR-181 family's role in key cell types that critically control cardiovascular inflammation under pathological and physiological stimuli.
AB - The microRNA family, miR-181, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Accumulating evidence supports a central role for the miR-181 family in vascular inflammation by controlling critical signaling pathways, such as downstream NF-κB signaling, and targets relevant to endothelial cell activation and immune cell homeostasis. This review examines the current knowledge of the miR-181 family's role in key cell types that critically control cardiovascular inflammation under pathological and physiological stimuli.
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U2 - 10.1016/j.tcm.2013.09.002
DO - 10.1016/j.tcm.2013.09.002
M3 - Review article
C2 - 24183793
AN - SCOPUS:84896706827
SN - 1050-1738
VL - 24
SP - 105
EP - 112
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 3
ER -