Role of natural killer cells in tumor growth and metastasis: C57BL/6 normal and beige mice

J. E. Talmadge, K. M. Meyers, D. J. Prieur, J. R. Starkey

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Abstract

The role of natural killer (NK) cells in tumor growth and metastasis was studied in syngeneic normal and beige inbred C57BL/6 mice. Mice with the beige point mutation have been shown to be deficient in nonstimulated NK activity. Tumor-passaged B16 malignant melanoma cells were refractory to NK activity as determined by in vitro assay, but after in vitro culture they became sensitive to NK activity. The NK-insensitive B16 tumor grew and metastasized similarly in normal and beige mice. However, the NK-sensitive B16 tumors grew more slowly and produced fewer metastases in normal mice than in NK-deficient beige mice. Activation of NK cells by lymphocytic choriomeningitis virus infection decreased the rate of growth and number of metastases of both NK-sensitive and NK-insensitive tumors in both normal and beige mice. These results suggest the importance of NK cells as a determinant to tumor growth and metastasis.

Original languageEnglish (US)
Pages (from-to)929-935
Number of pages7
JournalJournal of the National Cancer Institute
Volume65
Issue number5
StatePublished - Dec 1 1980

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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