Role of neighborhood context in ovarian cancer survival disparities: current research and future directions

Scarlett L. Gomez, Ekaterina Chirikova, Valerie McGuire, Lindsay J. Collin, Lauren Dempsey, Pushkar P. Inamdar, Katherine Lawson-Michod, Edward S. Peters, Lawrence H. Kushi, Juraj Kavecansky, Salma Shariff-Marco, Lauren C. Peres, Paul Terry, Elisa V. Bandera, Joellen M. Schildkraut, Jennifer A. Doherty, Andrew Lawson

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Ovarian cancer is the fifth leading cause of cancer-associated mortality among US women with survival disparities seen across race, ethnicity, and socioeconomic status, even after accounting for histology, stage, treatment, and other clinical factors. Neighborhood context can play an important role in ovarian cancer survival, and, to the extent to which minority racial and ethnic groups and populations of lower socioeconomic status are more likely to be segregated into neighborhoods with lower quality social, built, and physical environment, these contextual factors may be a critical component of ovarian cancer survival disparities. Understanding factors associated with ovarian cancer outcome disparities will allow clinicians to identify patients at risk for worse outcomes and point to measures, such as social support programs or transportation aid, that can help to ameliorate such disparities. However, research on the impact of neighborhood contextual factors in ovarian cancer survival and in disparities in ovarian cancer survival is limited. This commentary focuses on the following neighborhood contextual domains: structural and institutional context, social context, physical context represented by environmental exposures, built environment, rurality, and healthcare access. The research conducted to date is presented and clinical implications and recommendations for future interventions and studies to address disparities in ovarian cancer outcomes are proposed.

Original languageEnglish (US)
Pages (from-to)366-376.e8
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
StatePublished - Oct 2023


  • multilevel framework
  • ovarian cancer
  • race and ethnicity
  • social inequities
  • survival disparities

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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