A numerical study was performed to investigate the effect of ear openings on the dynamic brain response under blast loading condition. Transient nonlinear dynamic analysis of a cylindrical head was subjected to blast wave with a peak overpressure of 0.33 MPa and positive phase duration of 5 msec. The dynamic brain response is monitored in terms of intracranial pressures and shear stresses considering the opening in comparison to no opening case. The results have suggested increased intracranial pressures and shear stress in the brain with the presence of one opening. Furthermore, the opening also increased the fluctuation of stress wave through the skull with two times of increase in magnitude.