Role of the hyaluronan receptor, stabilin-2/hare, in health and disease

Edward N. Harris; Erika Baker

doi:10.3390/ijms21103504

Role of the hyaluronan receptor, stabilin-2/hare, in health and disease

Edward N. Harris, Erika Baker

Biochemistry

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to ligand binding, cellular signaling, and its role in known physiological disorders such as cancer.

Original language	English (US)
Article number	3504
Journal	International journal of molecular sciences
Volume	21
Issue number	10
DOIs	https://doi.org/10.3390/ijms21103504
State	Published - May 2 2020

Keywords

Clearance
HARE
Hyaluronan
Ligand
MAPK
Receptor
Signaling
Stabilin-2

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms21103504

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title = "Role of the hyaluronan receptor, stabilin-2/hare, in health and disease",

abstract = "Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to ligand binding, cellular signaling, and its role in known physiological disorders such as cancer.",

keywords = "Clearance, HARE, Hyaluronan, Ligand, MAPK, Receptor, Signaling, Stabilin-2",

author = "Harris, {Edward N.} and Erika Baker",

note = "Funding Information: Funding: This work was funded in part by the National Institutes of Health grant, HL130864. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

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N2 - Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to ligand binding, cellular signaling, and its role in known physiological disorders such as cancer.

AB - Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to ligand binding, cellular signaling, and its role in known physiological disorders such as cancer.

KW - Clearance

KW - HARE

KW - Hyaluronan

KW - Ligand

KW - MAPK

KW - Receptor

KW - Signaling

KW - Stabilin-2

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Role of the hyaluronan receptor, stabilin-2/hare, in health and disease

Abstract

Keywords

ASJC Scopus subject areas

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