Role of the hyaluronan receptor, stabilin-2/hare, in health and disease

Edward N. Harris, Erika Baker

Research output: Contribution to journalReview article

Abstract

Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to ligand binding, cellular signaling, and its role in known physiological disorders such as cancer.

Original languageEnglish (US)
Article number3504
JournalInternational journal of molecular sciences
Volume21
Issue number10
DOIs
StatePublished - May 2 2020

Keywords

  • Clearance
  • HARE
  • Hyaluronan
  • Ligand
  • MAPK
  • Receptor
  • Signaling
  • Stabilin-2

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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