Role of the Survivin gene in pathophysiology

Fengzhi Li, Michael G. Brattain

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

Although the roles of survivin in control of cancer cell division and apoptosis as well as targeting survivin for cancer therapeutics have been extensively explored and reviewed, the pathophysiological role of survivin in normal human cells/organs has not been deeply investigated or sufficiently reviewed. Studies in the latter area, however, appear to be important for the identification of different mechanisms of regulation and function of survivin in normal versus abnormal cells and tissues (including cancer), which might ultimately provide the basis for novel approaches for disease treatment with low toxicity. This Review is intended to summarize current observations in the literature related to the physiological and/or pathological roles for survivin in various normal human cells or organs. Our view of potential future research directions for survivin pertinent to potential therapeutic applications will also be discussed.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalAmerican Journal of Pathology
Volume169
Issue number1
DOIs
StatePublished - Jul 2006
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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