Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options

Shetty Ravi Dyavar, Rahul Singh, Rohini Emani, Ganesh P. Pawar, Vinod D. Chaudhari, Anthony T. Podany, Sean N. Avedissian, Courtney V. Fletcher, Deepak B. Salunke

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is the causative agent of Corona Virus Disease 2019 (COVID-19). Lower production of type I and III interferons and higher levels of inflammatory mediators upon SARS-CoV2 infection contribute to COVID-19 pathogenesis. Optimal interferon production and controlled inflammation are essential to limit COVID-19 pathogenesis. However, the aggravated inflammatory response observed in COVID-19 patients causes severe damage to the host and frequently advances to acute respiratory distress syndrome (ARDS). Toll-like receptor 7 and 8 (TLR7/8) signaling pathways play a central role in regulating induction of interferons (IFNs) and inflammatory mediators in dendritic cells. Controlled inflammation is possible through regulation of TLR mediated response without influencing interferon production to reduce COVID-19 pathogenesis. This review focuses on inflammatory mediators that contribute to pathogenic effects and the role of TLR pathways in the induction of interferon and inflammatory mediators and their contribution to COVID-19 pathogenesis. We conclude that potential TLR7/8 agonists inducing antiviral interferon response and controlling inflammation are important therapeutic options to effectively eliminate SARS-CoV2 induced pathogenesis. Ongoing and future studies may provide additional evidence on their safety and efficacy to treat COVID-19 pathogenesis.

Original languageEnglish (US)
Article number111794
JournalBiomedicine and Pharmacotherapy
Volume141
DOIs
StatePublished - Sep 2021

Keywords

  • COVID-19
  • IL-1β
  • IL-6
  • SARS-CoV2
  • TLR7
  • TLR7/8 agonists
  • TLR8
  • Type I interferons

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options'. Together they form a unique fingerprint.

Cite this