Abstract
Human immunodeficiency virus (HIV)-1 and HIV-2 originated from cross-species transmission of simian immunodeficiency viruses (SIVs). Most of these transfers resulted in limited spread of these viruses to humans. However, one transmission event involving SIVcpz from chimpanzees gave rise to group M HIV-1, with M being the principal strain of HIV-1 responsible for the AIDS pandemic. Vpu is an HIV-1 accessory protein generated from Env/Vpu encoded bicistronic mRNA and localized in cytosolic and membrane regions of cells capable of being infected by HIV-1 and that regulate HIV-1 infection and transmission by downregulating BST-2, CD4 proteins levels, and immune evasion. This review will focus of critical aspects of Vpu including its zoonosis, the adaptive hurdles to cross-species transmission, and future perspectives and broad implications of Vpu in HIV-1 infection and dissemination.
| Original language | English (US) |
|---|---|
| Article number | 1466 |
| Journal | Viruses |
| Volume | 13 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2021 |
Keywords
- Autophagy
- Bone marrow stromal antigen 2
- Endolysosomes
- Endoplasmic reticulum-associated degradation pathway
- Endosomal sorting complexes required for transport
- Human immunodeficiency virus-1 and-2
- Simian immunodeficiency viruses
- Transmembrane domain
- Viral protein U (Vpu)
ASJC Scopus subject areas
- Infectious Diseases
- Virology