Room-temperature nucleophilic aromatic fluorination: Experimental and theoretical studies

Haoran Sun, Stephen G. DiMagno

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


(Chemical Equation Presented) Taming the reagent: The use of anhydrous tetrabutylammonium fluoride (TBAFanh) in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes (see scheme), was investigated. It was shown that TBAFanh permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.

Original languageEnglish (US)
Pages (from-to)2720-2725
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number17
StatePublished - Apr 21 2006
Externally publishedYes


  • Density functional calculations
  • Fluorine nucleophilic aromatic substitution
  • Synthetic methods
  • Tetrabutylammonium fluoride

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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