Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis

Jun Ting Fan; Yi Shan Chen; Wen Yan Xu; Liangcheng Du; Guang Zhi Zeng; Yu Mei Zhang; Jia Su; Yan Li; Ning Hua Tan

doi:10.1016/j.tetlet.2010.07.066

Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis

Jun Ting Fan, Yi Shan Chen, Wen Yan Xu, Liangcheng Du, Guang Zhi Zeng, Yu Mei Zhang, Jia Su, Yan Li, Ning Hua Tan

Chemistry

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.

Original language	English (US)
Pages (from-to)	6810-6813
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	52
DOIs	https://doi.org/10.1016/j.tetlet.2010.07.066
State	Published - Dec 29 2010

Keywords

Cyclopeptides
Cytotoxicity
Inhibition of NO production
Rubia yunnanensis
Rubiyunnanin A
Rubiyunnanin B

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2010.07.066

Cite this

@article{299a0fcc16db46be8e1ca4b1e1cd9fa1,

title = "Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis",

abstract = "Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.",

keywords = "Cyclopeptides, Cytotoxicity, Inhibition of NO production, Rubia yunnanensis, Rubiyunnanin A, Rubiyunnanin B",

author = "Fan, {Jun Ting} and Chen, {Yi Shan} and Xu, {Wen Yan} and Liangcheng Du and Zeng, {Guang Zhi} and Zhang, {Yu Mei} and Jia Su and Yan Li and Tan, {Ning Hua}",

note = "Funding Information: This work was financially supported by the National Natural Science Foundation of China ( 30725048 ), National Basic Research Program of China ( 2009 CB522300 ), the Innovative Group Program from the Science and Technology Department of Yunnan Province ( 2008OC011 ), and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences . ",

year = "2010",

month = dec,

day = "29",

doi = "10.1016/j.tetlet.2010.07.066",

language = "English (US)",

volume = "51",

pages = "6810--6813",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "52",

}

TY - JOUR

T1 - Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis

AU - Fan, Jun Ting

AU - Chen, Yi Shan

AU - Xu, Wen Yan

AU - Du, Liangcheng

AU - Zeng, Guang Zhi

AU - Zhang, Yu Mei

AU - Su, Jia

AU - Li, Yan

AU - Tan, Ning Hua

N1 - Funding Information: This work was financially supported by the National Natural Science Foundation of China ( 30725048 ), National Basic Research Program of China ( 2009 CB522300 ), the Innovative Group Program from the Science and Technology Department of Yunnan Province ( 2008OC011 ), and the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences .

PY - 2010/12/29

Y1 - 2010/12/29

N2 - Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.

AB - Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.

KW - Cyclopeptides

KW - Cytotoxicity

KW - Inhibition of NO production

KW - Rubia yunnanensis

KW - Rubiyunnanin A

KW - Rubiyunnanin B

UR - http://www.scopus.com/inward/record.url?scp=78249266639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78249266639&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2010.07.066

DO - 10.1016/j.tetlet.2010.07.066

M3 - Article

AN - SCOPUS:78249266639

VL - 51

SP - 6810

EP - 6813

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 52

ER -

Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this