Abstract
Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.
Original language | English (US) |
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Pages (from-to) | 6810-6813 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 52 |
DOIs | |
State | Published - Dec 29 2010 |
Keywords
- Cyclopeptides
- Cytotoxicity
- Inhibition of NO production
- Rubia yunnanensis
- Rubiyunnanin A
- Rubiyunnanin B
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry