Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis

Jun Ting Fan, Yi Shan Chen, Wen Yan Xu, Liangcheng Du, Guang Zhi Zeng, Yu Mei Zhang, Jia Su, Yan Li, Ning Hua Tan

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.

Original languageEnglish (US)
Pages (from-to)6810-6813
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number52
DOIs
StatePublished - Dec 29 2010

Keywords

  • Cyclopeptides
  • Cytotoxicity
  • Inhibition of NO production
  • Rubia yunnanensis
  • Rubiyunnanin A
  • Rubiyunnanin B

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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