Saccharin-Induced Hyperplasia of the Rat Urinary Bladder

Shoji Fukushima, Samuel M. Cohen

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


Dietary administration of sodium saccharin to male Fischer rats increased the rate of DNA synthesis of the urinary bladder epithelium as measured by tritiated thymidine uptake. A multifocal mild epithelial hyperplasia was induced, which was most readily detected by scanning electron microscopy, with pleomorphic microvilli present on many of the hyperplastic cells.

Original languageEnglish (US)
Pages (from-to)734-736
Number of pages3
JournalCancer Research
Issue number3
StatePublished - Mar 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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