Safety of saccharin

Samuel M. Cohen, Lora L. Arnold, James L. Emerson

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Long term treatment with high doses of sodium saccharin in the diet beginning in utero or at birth induces urinary bladder tumours in the rat with a higher incidence in male rats compared to female rats. After one of the most extensive toxicological evaluations of any chemical, it ultimately was shown that saccharin-induced bladder cancer in rats is a species-specific high dose phenomenon, and It is now accepted that saccharin does not pose a cancer risk to humans. The methodology utilized and the issues investigated in the research with saccharin have greatly extended the sciences of toxicology, epidemiology and risk assessment for chemicals.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalAgro Food Industry Hi-Tech
Issue number6
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering


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