Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children

Anu Nurkka; Jenny MacLennan; Virva Jäntti; Steven Obaro; Brian Greenwood; Helena Käyhty

doi:10.1016/S0264-410X(00)00180-8

Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children

Anu Nurkka, Jenny MacLennan, Virva Jäntti, Steven Obaro, Brian Greenwood, Helena Käyhty

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	547-556
Number of pages	10
Journal	Vaccine
Volume	19
Issue number	4-5
DOIs	https://doi.org/10.1016/S0264-410X(00)00180-8
State	Published - Oct 15 2000
Externally published	Yes

Keywords

Meningococcal vaccines
Salivary antibodies

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(00)00180-8

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title = "Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children",

abstract = "Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.",

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AU - Nurkka, Anu

AU - MacLennan, Jenny

AU - Jäntti, Virva

AU - Obaro, Steven

AU - Greenwood, Brian

AU - Käyhty, Helena

PY - 2000/10/15

Y1 - 2000/10/15

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AB - Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.

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