Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children

Anu Nurkka; Jenny MacLennan; Virva Jäntti; Steven Obaro; Brian Greenwood; Helena Käyhty

doi:10.1016/S0264-410X(00)00180-8

Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children

Anu Nurkka, Jenny MacLennan, Virva Jäntti, Steven Obaro, Brian Greenwood, Helena Käyhty

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	547-556
Number of pages	10
Journal	Vaccine
Volume	19
Issue number	4-5
DOIs	https://doi.org/10.1016/S0264-410X(00)00180-8
State	Published - Oct 15 2000
Externally published	Yes

Keywords

Meningococcal vaccines
Salivary antibodies

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(00)00180-8

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title = "Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children",

abstract = "Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.",

keywords = "Meningococcal vaccines, Salivary antibodies",

author = "Anu Nurkka and Jenny MacLennan and Virva J{\"a}ntti and Steven Obaro and Brian Greenwood and Helena K{\"a}yhty",

note = "Funding Information: We want to thank the children who took part in the study, Field and Laboratory staff at the Medical Research Council, The Gambia, for their assistance with field work and handling the samples, Lorna Pais and George Carlone at CDC for undertaking the serum ELISA assays, Juhani Eskola and Maida Korkeila for critical reading of the manuscript, and National Meningitis Trust for funding of the study.",

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doi = "10.1016/S0264-410X(00)00180-8",

language = "English (US)",

volume = "19",

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T1 - Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children

AU - Nurkka, Anu

AU - MacLennan, Jenny

AU - Jäntti, Virva

AU - Obaro, Steven

AU - Greenwood, Brian

AU - Käyhty, Helena

N1 - Funding Information: We want to thank the children who took part in the study, Field and Laboratory staff at the Medical Research Council, The Gambia, for their assistance with field work and handling the samples, Lorna Pais and George Carlone at CDC for undertaking the serum ELISA assays, Juhani Eskola and Maida Korkeila for critical reading of the manuscript, and National Meningitis Trust for funding of the study.

PY - 2000/10/15

Y1 - 2000/10/15

N2 - Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.

AB - Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.

KW - Meningococcal vaccines

KW - Salivary antibodies

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AN - SCOPUS:0034668154

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EP - 556

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 4-5

ER -

Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children

Abstract

Keywords

ASJC Scopus subject areas

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