Abstract
Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 547-556 |
| Number of pages | 10 |
| Journal | Vaccine |
| Volume | 19 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - Oct 15 2000 |
Keywords
- Meningococcal vaccines
- Salivary antibodies
ASJC Scopus subject areas
- Molecular Medicine
- Immunology and Microbiology(all)
- veterinary(all)
- Public Health, Environmental and Occupational Health
- Infectious Diseases
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Nurkka, A., MacLennan, J., Jäntti, V., Obaro, S., Greenwood, B., & Käyhty, H. (2000). Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children. Vaccine, 19(4-5), 547-556. https://doi.org/10.1016/S0264-410X(00)00180-8