TY - JOUR
T1 - Samarium-153-EDTMP in the treatment of refractory rheumatoid arthritis
AU - Mikuls, T. R.
AU - Kahn, D.
AU - Utrie, P. C.
AU - Miller, S. J.
AU - Koehnke, R.
AU - Goeckeler, W.
AU - Saag, K. G.
PY - 2001
Y1 - 2001
N2 - We examined the preliminary safety and efficacy of intravenous samarium-153-EDTMP (Sm-153) in the treatment of refractory rheumatoid arthritis (RA). In an open-label sequential group comparison of 0.5, 1.0, and 2.0 mCi/kg, Sm-153 was administered as a single intravenous infusion to 24 patients with refractory disease. Across treatment doses, the frequency of American College of Rheumatology (ACR) 20% responses was 25%, 29%, 25%, and 33% at 2, 4, 8, and 12 weeks, respectively. Expected significant declines in absolute neutrophil count, hemoglobin, and platelet counts were observed with nadirs seen between 2-4 weeks. Sm-153, at doses of 0.5 and 1.0mCi/kg, is well tolerated but minimally effective in the treatment of refractory RA as measured using ACR response criteria.
AB - We examined the preliminary safety and efficacy of intravenous samarium-153-EDTMP (Sm-153) in the treatment of refractory rheumatoid arthritis (RA). In an open-label sequential group comparison of 0.5, 1.0, and 2.0 mCi/kg, Sm-153 was administered as a single intravenous infusion to 24 patients with refractory disease. Across treatment doses, the frequency of American College of Rheumatology (ACR) 20% responses was 25%, 29%, 25%, and 33% at 2, 4, 8, and 12 weeks, respectively. Expected significant declines in absolute neutrophil count, hemoglobin, and platelet counts were observed with nadirs seen between 2-4 weeks. Sm-153, at doses of 0.5 and 1.0mCi/kg, is well tolerated but minimally effective in the treatment of refractory RA as measured using ACR response criteria.
KW - Radioisotope
KW - Rheumatoid arthritis
KW - Samarium-153-EDTMP
KW - Treatment
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U2 - 10.1080/030097401317148561
DO - 10.1080/030097401317148561
M3 - Article
C2 - 11846055
AN - SCOPUS:0035665768
SN - 0300-9742
VL - 30
SP - 356
EP - 359
JO - Scandinavian Journal of Rheumatology
JF - Scandinavian Journal of Rheumatology
IS - 6
ER -