Sarcoidosis and antiphospholipid syndrome: A systematic review of cases

Ranjan Pathak, Raju Khanal, Madan Raj Aryal, Smith Giri, Paras Karmacharya, Basanta Pathak, Upasana Acharya, Vijaya Raj Bhatt

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Association between sarcoidosis and antiphospholipid syndrome (APS) is rare with few reported cases. We sought to systematically review the published cases of APS with sarcoidosis to better characterize the demographics, clinical characteristics, treatment, and the outcome of this association. Systematic electronic search for case report, case series, and related articles published until May 2014 was carried out and relevant data were extracted and analyzed. Four cases of APS with sarcoidosis were identifi ed exclusively in females. These cases were seen in the sixth decade of life. Pulmonary embolism and central retinal artery occlusion were the presenting thrombotic events. All the patients were treated with lifelong anticoagulation with warfarin. During the median follow-up period of 5.5 months, additional thrombotic events were not observed. Although rare, sarcoidosis may be associated with APS. Further reporting of the cases will help to better establish this association, elucidate pathogenesis, and defi ne clinical characteristics and outcomes.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalNorth American Journal of Medical Sciences
Issue number9
StatePublished - Sep 1 2015


  • Antiphospholipid syndrome
  • Association
  • Sarcoidosis
  • Systematic review

ASJC Scopus subject areas

  • Medicine(all)


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