TY - JOUR
T1 - Sarcoidosis and antiphospholipid syndrome
T2 - A systematic review of cases
AU - Pathak, Ranjan
AU - Khanal, Raju
AU - Aryal, Madan Raj
AU - Giri, Smith
AU - Karmacharya, Paras
AU - Pathak, Basanta
AU - Acharya, Upasana
AU - Bhatt, Vijaya Raj
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Association between sarcoidosis and antiphospholipid syndrome (APS) is rare with few reported cases. We sought to systematically review the published cases of APS with sarcoidosis to better characterize the demographics, clinical characteristics, treatment, and the outcome of this association. Systematic electronic search for case report, case series, and related articles published until May 2014 was carried out and relevant data were extracted and analyzed. Four cases of APS with sarcoidosis were identifi ed exclusively in females. These cases were seen in the sixth decade of life. Pulmonary embolism and central retinal artery occlusion were the presenting thrombotic events. All the patients were treated with lifelong anticoagulation with warfarin. During the median follow-up period of 5.5 months, additional thrombotic events were not observed. Although rare, sarcoidosis may be associated with APS. Further reporting of the cases will help to better establish this association, elucidate pathogenesis, and defi ne clinical characteristics and outcomes.
AB - Association between sarcoidosis and antiphospholipid syndrome (APS) is rare with few reported cases. We sought to systematically review the published cases of APS with sarcoidosis to better characterize the demographics, clinical characteristics, treatment, and the outcome of this association. Systematic electronic search for case report, case series, and related articles published until May 2014 was carried out and relevant data were extracted and analyzed. Four cases of APS with sarcoidosis were identifi ed exclusively in females. These cases were seen in the sixth decade of life. Pulmonary embolism and central retinal artery occlusion were the presenting thrombotic events. All the patients were treated with lifelong anticoagulation with warfarin. During the median follow-up period of 5.5 months, additional thrombotic events were not observed. Although rare, sarcoidosis may be associated with APS. Further reporting of the cases will help to better establish this association, elucidate pathogenesis, and defi ne clinical characteristics and outcomes.
KW - Antiphospholipid syndrome
KW - Association
KW - Sarcoidosis
KW - Systematic review
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U2 - 10.4103/1947-2714.166213
DO - 10.4103/1947-2714.166213
M3 - Review article
C2 - 26605200
AN - SCOPUS:84943196448
VL - 7
SP - 379
EP - 383
JO - North American Journal of Medical Sciences
JF - North American Journal of Medical Sciences
SN - 2250-1541
IS - 9
ER -