Sarcomas of the vagina and uterus: The intergroup rhabdomyosarcoma study

Daniel M. Hays, Hiroyuki Shimada, R. Beverly Raney, Melvin Tefft, William Newton, William M. Crist, Walter Lawrence, Abdel Ragab, Harold M. Maurer

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


During a 12-year period (1972-1984), 43 patients with sarcomas of the female genital tract were admitted to the Intergroup Rhabdomyosarcoma Study (IRS), including 31 with primary tumors of the vagina; and 12 with tumors of the uterus, including the cervix. Thirty-four of these can be evaluated on the basis of periods of observation from 18 months to 12 years. Primary tumors of the uterus were a distinct group, distinguished from those arising in the vagina by patient age-range and probably by prognosis, as well as site. Patients with vaginal tumors, with a mean age of 1.8 years, responded to a multimodality approach employing combinations of chemotherapy (vincristine sulfate and actinomycin D, or the aforementioned two drugs with cyclophosphamide ± doxorubicin hydrochloride), irradiation, and/or surgery, with only one tumor-related death, among 24 evaluable patients. In contrast, among the patients with primary uterine tumors, in which the mean age was > 14 years, four of ten evaluable patients died secondary to tumor relapse or progression.

Original languageEnglish (US)
Pages (from-to)718-724
Number of pages7
JournalJournal of pediatric surgery
Issue number6
StatePublished - Dec 1985
Externally publishedYes


  • Sarcoma, vagina
  • rhabdomyosarcoma
  • sarcoma, uterus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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