TY - JOUR
T1 - Sarcomas of the vagina and uterus
T2 - The intergroup rhabdomyosarcoma study
AU - Hays, Daniel M.
AU - Shimada, Hiroyuki
AU - Raney, R. Beverly
AU - Tefft, Melvin
AU - Newton, William
AU - Crist, William M.
AU - Lawrence, Walter
AU - Ragab, Abdel
AU - Maurer, Harold M.
N1 - Funding Information:
From the Intergroup Rhabdomyosarcoma Committee, representing the Pediatric Oncotogy Group and Children's Cancer Study Group: Denman Hammond, Ruth Heyn, Frederick Ruymann, Moody Wharam, Mohan Beltangady, and Edmund Gehan. Supported by US Public Health Service Grant Nos. CA 03735, CA 24507, CA 30138, CA 30969, CA 29139, CA 10214, and CA 13539 9 Presented before the 16th Annual Meeting of the American Pediatric Surgical Association, Kohala Coast, Hawaii, May !-4, 1985. Address reprint requests to the Childrens Hospital of Los Angeles, PO Box 54700, Terminal Annex, Los Angeles, CA 90054 9 9 1985 by Grune & Stratton, Inc. 0022-3468/85/2006-0031 $03 9
PY - 1985/12
Y1 - 1985/12
N2 - During a 12-year period (1972-1984), 43 patients with sarcomas of the female genital tract were admitted to the Intergroup Rhabdomyosarcoma Study (IRS), including 31 with primary tumors of the vagina; and 12 with tumors of the uterus, including the cervix. Thirty-four of these can be evaluated on the basis of periods of observation from 18 months to 12 years. Primary tumors of the uterus were a distinct group, distinguished from those arising in the vagina by patient age-range and probably by prognosis, as well as site. Patients with vaginal tumors, with a mean age of 1.8 years, responded to a multimodality approach employing combinations of chemotherapy (vincristine sulfate and actinomycin D, or the aforementioned two drugs with cyclophosphamide ± doxorubicin hydrochloride), irradiation, and/or surgery, with only one tumor-related death, among 24 evaluable patients. In contrast, among the patients with primary uterine tumors, in which the mean age was > 14 years, four of ten evaluable patients died secondary to tumor relapse or progression.
AB - During a 12-year period (1972-1984), 43 patients with sarcomas of the female genital tract were admitted to the Intergroup Rhabdomyosarcoma Study (IRS), including 31 with primary tumors of the vagina; and 12 with tumors of the uterus, including the cervix. Thirty-four of these can be evaluated on the basis of periods of observation from 18 months to 12 years. Primary tumors of the uterus were a distinct group, distinguished from those arising in the vagina by patient age-range and probably by prognosis, as well as site. Patients with vaginal tumors, with a mean age of 1.8 years, responded to a multimodality approach employing combinations of chemotherapy (vincristine sulfate and actinomycin D, or the aforementioned two drugs with cyclophosphamide ± doxorubicin hydrochloride), irradiation, and/or surgery, with only one tumor-related death, among 24 evaluable patients. In contrast, among the patients with primary uterine tumors, in which the mean age was > 14 years, four of ten evaluable patients died secondary to tumor relapse or progression.
KW - Sarcoma, vagina
KW - rhabdomyosarcoma
KW - sarcoma, uterus
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U2 - 10.1016/S0022-3468(85)80032-4
DO - 10.1016/S0022-3468(85)80032-4
M3 - Article
C2 - 3910785
AN - SCOPUS:0022368274
SN - 0022-3468
VL - 20
SP - 718
EP - 724
JO - Journal of pediatric surgery
JF - Journal of pediatric surgery
IS - 6
ER -