A number of neurological disease complications have been seen following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While most person with COVID-19 respiratory disease demonstrate headache, nausea and vomiting, up to 40% present also experience dizziness, confusion, cerebrovascular disease, muscle pain, ataxia and seizures. Loss of taste and smell, defects in visual acuity and pain occur in parallel. Such central nervous system (CNS) signs and symptoms linked to laboratory-confirmed SARS-CoV-2 infection is often life threatening. Health care providers currently evaluating patients with neurologic symptoms need consider COVID-19 in any differential diagnosis. These considerations will facilitate prompt testing, isolation and prevention of viral transmission speeding best clinical outcomes. [Figure not available: see fulltext.].

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalJournal of Neuroimmune Pharmacology
Issue number2
StatePublished - Jun 1 2020


  • Animal models
  • CNS
  • COVID-19
  • Guillain-Barré syndrome
  • Neurologic manifestations
  • SARS-CoV-2
  • Therapeutics

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology


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