SARS-CoV-2 infection of the placenta

Hillary Hosier; Shelli F. Farhadian; Raffaella A. Morotti; Uma Deshmukh; Alice Lu-Culligan; Katherine H. Campbell; Yuki Yasumoto; Chantal B.F. Vogels; Arnau Casanovas-Massana; Pavithra Vijayakumar; Bertie Geng; Camila D. Odio; John Fournier; Anderson F. Brito; Joseph R. Fauver; Feimei Liu; Tara Alpert; Reshef Tal; Klara Szigeti-Buck; Sudhir Perincheri; Christopher Larsen; Aileen M. Gariepy; Gabriela Aguilar; Kristen L. Fardelmann; Malini Harigopal; Hugh S. Taylor; Christian M. Pettker; Anne L. Wyllie; Charles Dela Cruz; Aaron M. Ring; Nathan D. Grubaugh; Albert I. Ko; Tamas L. Horvath; Akiko Iwasaki; Uma M. Reddy; Heather S. Lipkind

doi:10.1172/JCI139569

SARS-CoV-2 infection of the placenta

Hillary Hosier, Shelli F. Farhadian, Raffaella A. Morotti, Uma Deshmukh, Alice Lu-Culligan, Katherine H. Campbell, Yuki Yasumoto, Chantal B.F. Vogels, Arnau Casanovas-Massana, Pavithra Vijayakumar, Bertie Geng, Camila D. Odio, John Fournier, Anderson F. Brito, Joseph R. Fauver, Feimei Liu, Tara Alpert, Reshef Tal, Klara Szigeti-Buck, Sudhir PerincheriChristopher Larsen, Aileen M. Gariepy, Gabriela Aguilar, Kristen L. Fardelmann, Malini Harigopal, Hugh S. Taylor, Christian M. Pettker, Anne L. Wyllie, Charles Dela Cruz, Aaron M. Ring, Nathan D. Grubaugh, Albert I. Ko, Tamas L. Horvath, Akiko Iwasaki, Uma M. Reddy, Heather S. Lipkind

Research output: Contribution to journal › Article › peer-review

351 Scopus citations

Abstract

BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption. METHODS. We analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection. RESULTS. SARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for the vasculopathy typically associated with preeclampsia. CONCLUSION. This case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with COVID-19.

Original language	English (US)
Pages (from-to)	4947-4953
Number of pages	7
Journal	Journal of Clinical Investigation
Volume	130
Issue number	9
DOIs	https://doi.org/10.1172/JCI139569
State	Published - Sep 1 2020
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Hosier, H., Farhadian, S. F., Morotti, R. A., Deshmukh, U., Lu-Culligan, A., Campbell, K. H., Yasumoto, Y., Vogels, C. B. F., Casanovas-Massana, A., Vijayakumar, P., Geng, B., Odio, C. D., Fournier, J., Brito, A. F., Fauver, J. R., Liu, F., Alpert, T., Tal, R., Szigeti-Buck, K., ... Lipkind, H. S. (2020). SARS-CoV-2 infection of the placenta. Journal of Clinical Investigation, 130(9), 4947-4953. https://doi.org/10.1172/JCI139569

Hosier, H, Farhadian, SF, Morotti, RA, Deshmukh, U, Lu-Culligan, A, Campbell, KH, Yasumoto, Y, Vogels, CBF, Casanovas-Massana, A, Vijayakumar, P, Geng, B, Odio, CD, Fournier, J, Brito, AF, Fauver, JR, Liu, F, Alpert, T, Tal, R, Szigeti-Buck, K, Perincheri, S, Larsen, C, Gariepy, AM, Aguilar, G, Fardelmann, KL, Harigopal, M, Taylor, HS, Pettker, CM, Wyllie, AL, Dela Cruz, C, Ring, AM, Grubaugh, ND, Ko, AI, Horvath, TL, Iwasaki, A, Reddy, UM & Lipkind, HS 2020, 'SARS-CoV-2 infection of the placenta', Journal of Clinical Investigation, vol. 130, no. 9, pp. 4947-4953. https://doi.org/10.1172/JCI139569

@article{1683d088ddb94d0aaac3223c1654379c,

title = "SARS-CoV-2 infection of the placenta",

abstract = "BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption. METHODS. We analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection. RESULTS. SARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for the vasculopathy typically associated with preeclampsia. CONCLUSION. This case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with COVID-19.",

author = "Hillary Hosier and Farhadian, {Shelli F.} and Morotti, {Raffaella A.} and Uma Deshmukh and Alice Lu-Culligan and Campbell, {Katherine H.} and Yuki Yasumoto and Vogels, {Chantal B.F.} and Arnau Casanovas-Massana and Pavithra Vijayakumar and Bertie Geng and Odio, {Camila D.} and John Fournier and Brito, {Anderson F.} and Fauver, {Joseph R.} and Feimei Liu and Tara Alpert and Reshef Tal and Klara Szigeti-Buck and Sudhir Perincheri and Christopher Larsen and Gariepy, {Aileen M.} and Gabriela Aguilar and Fardelmann, {Kristen L.} and Malini Harigopal and Taylor, {Hugh S.} and Pettker, {Christian M.} and Wyllie, {Anne L.} and {Dela Cruz}, Charles and Ring, {Aaron M.} and Grubaugh, {Nathan D.} and Ko, {Albert I.} and Horvath, {Tamas L.} and Akiko Iwasaki and Reddy, {Uma M.} and Lipkind, {Heather S.}",

note = "Publisher Copyright: {\textcopyright} 2020, American Society for Clinical Investigation.",

year = "2020",

month = sep,

day = "1",

doi = "10.1172/JCI139569",

language = "English (US)",

volume = "130",

pages = "4947--4953",

journal = "Journal of Clinical Investigation",

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publisher = "The American Society for Clinical Investigation",

number = "9",

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TY - JOUR

T1 - SARS-CoV-2 infection of the placenta

AU - Hosier, Hillary

AU - Farhadian, Shelli F.

AU - Morotti, Raffaella A.

AU - Deshmukh, Uma

AU - Lu-Culligan, Alice

AU - Campbell, Katherine H.

AU - Yasumoto, Yuki

AU - Vogels, Chantal B.F.

AU - Casanovas-Massana, Arnau

AU - Vijayakumar, Pavithra

AU - Geng, Bertie

AU - Odio, Camila D.

AU - Fournier, John

AU - Brito, Anderson F.

AU - Fauver, Joseph R.

AU - Liu, Feimei

AU - Alpert, Tara

AU - Tal, Reshef

AU - Szigeti-Buck, Klara

AU - Perincheri, Sudhir

AU - Larsen, Christopher

AU - Gariepy, Aileen M.

AU - Aguilar, Gabriela

AU - Fardelmann, Kristen L.

AU - Harigopal, Malini

AU - Taylor, Hugh S.

AU - Pettker, Christian M.

AU - Wyllie, Anne L.

AU - Dela Cruz, Charles

AU - Ring, Aaron M.

AU - Grubaugh, Nathan D.

AU - Ko, Albert I.

AU - Horvath, Tamas L.

AU - Iwasaki, Akiko

AU - Reddy, Uma M.

AU - Lipkind, Heather S.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption. METHODS. We analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection. RESULTS. SARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for the vasculopathy typically associated with preeclampsia. CONCLUSION. This case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with COVID-19.

AB - BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption. METHODS. We analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection. RESULTS. SARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for the vasculopathy typically associated with preeclampsia. CONCLUSION. This case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with COVID-19.

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DO - 10.1172/JCI139569

M3 - Article

C2 - 32573498

AN - SCOPUS:85087420435

SN - 0021-9738

VL - 130

SP - 4947

EP - 4953

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 9

ER -

SARS-CoV-2 infection of the placenta

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