Scaffold structural microenvironmental cues to guide tissue regeneration in bone tissue applications

Xuening Chen, Hongyuan Fan, Xiaowei Deng, Lina Wu, Tao Yi, Linxia Gu, Changchun Zhou, Yujiang Fan, Xingdong Zhang

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


In the process of bone regeneration, new bone formation is largely affected by physico-chemical cues in the surrounding microenvironment. Tissue cells reside in a complex scaffold physiological microenvironment. The scaffold should provide certain circumstance full of structural cues to enhance multipotent mesenchymal stem cell (MSC) differentiation, osteoblast growth, extracellular matrix (ECM) deposition, and subsequent new bone formation. This article reviewed advances in fabrication technology that enable the creation of biomaterials with well-defined pore structure and surface topography, which can be sensed by host tissue cells (esp., stem cells) and subsequently determine cell fates during differentiation. Three important cues, including scaffold pore structure (i.e., porosity and pore size), grain size, and surface topography were studied. These findings improve our understanding of how the mechanism scaffold microenvironmental cues guide bone tissue regeneration.

Original languageEnglish (US)
Article number960
Issue number11
StatePublished - Nov 21 2018


  • Bone tissue regeneration
  • Grain size
  • Porosity
  • Structural microenvironmental cues
  • Surface topography

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)


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