Searching for electrical properties, phenomena and mechanisms in the construction and function of chromosomes

Ivan Kanev, Wai Ning Mei, Akira Mizuno, Kristi Dehaai, Jennifer Sanmann, Michelle Hess, Lois Starr, Jennifer Grove, Bhavana Dave, Warren Sanger

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Our studies reveal previously unidentified electrical properties of chromosomes: (1) chromosomes are amazingly similar in construction and function to electrical transformers; (2) chromosomes possess in their construction and function, components similar to those of electric generators, conductors, condensers, switches, and other components of electrical circuits; (3) chromosomes demonstrate in nano-scale level electromagnetic interactions, resonance, fusion and other phenomena similar to those described by equations in classical physics. These electrical properties and phenomena provide a possible explanation for unclear and poorly understood mechanisms in clinical genetics including: (a) electrically based mechanisms responsible for breaks, translocations, fusions, and other chromosomal abnormalities associated with cancer, intellectual disability, infertility, pregnancy loss, Down syndrome, and other genetic disorders; (b) electrically based mechanisms involved in crossing over, non-disjunction and other events during meiosis and mitosis; (c) mechanisms demonstrating heterochromatin to be electrically active and genetically important.

Original languageEnglish (US)
Article numbera10
Pages (from-to)e201303007
JournalComputational and Structural Biotechnology Journal
Volume6
Issue number7
DOIs
StatePublished - Mar 2013

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Genetics
  • Computer Science Applications

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