Searching for significance in TCR-cytoskeleton interactions

Steve Caplan; Michal Baniyash

doi:10.1016/S0167-5699(00)01604-2

Searching for significance in TCR-cytoskeleton interactions

Steve Caplan, Michal Baniyash

Research output: Contribution to journal › Comment/debate › peer-review

28 Scopus citations

Abstract

Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.

Original language	English (US)
Pages (from-to)	223-228
Number of pages	6
Journal	Immunology Today
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/S0167-5699(00)01604-2
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/S0167-5699(00)01604-2

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@article{e63efbdd50934660ae72392f0bedccd6,

title = "Searching for significance in TCR-cytoskeleton interactions",

abstract = "Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.",

author = "Steve Caplan and Michal Baniyash",

note = "Funding Information: We thank G. Berke, L. Wang and N. Naslavsky for their critical advice, and acknowledge the support of the Society for Research Associates of the Lautenberg Center, the United States-Israel Binational Science Foundation, the Concern Foundation of Los Angeles and the Abisch-Frankel Foundation for the Life Sciences. We apologize that owing to space constraints we were unable to cite all of the many relevant references in this rapidly growing field.",

year = "2000",

doi = "10.1016/S0167-5699(00)01604-2",

language = "English (US)",

volume = "21",

pages = "223--228",

journal = "Immunology Today",

issn = "0167-5699",

publisher = "Elsevier Ltd",

number = "5",

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TY - JOUR

T1 - Searching for significance in TCR-cytoskeleton interactions

AU - Caplan, Steve

AU - Baniyash, Michal

N1 - Funding Information: We thank G. Berke, L. Wang and N. Naslavsky for their critical advice, and acknowledge the support of the Society for Research Associates of the Lautenberg Center, the United States-Israel Binational Science Foundation, the Concern Foundation of Los Angeles and the Abisch-Frankel Foundation for the Life Sciences. We apologize that owing to space constraints we were unable to cite all of the many relevant references in this rapidly growing field.

PY - 2000

Y1 - 2000

N2 - Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.

AB - Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.

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U2 - 10.1016/S0167-5699(00)01604-2

DO - 10.1016/S0167-5699(00)01604-2

M3 - Comment/debate

C2 - 10782053

AN - SCOPUS:0034026493

SN - 0167-5699

VL - 21

SP - 223

EP - 228

JO - Immunology Today

JF - Immunology Today

IS - 5

ER -

Searching for significance in TCR-cytoskeleton interactions

Abstract

ASJC Scopus subject areas

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