Abstract
The left-ventricular (LV) functional, hemodynamic, and antiadrenergic effects of metoprolol, bucindolol, and carvedilol have been compared in three concurrent placebo-controlled clinical trials in patients with symptomatic idiopathic dilated cardiomyopathy. All three drugs were well tolerated, all produced at least moderate degrees of β-blockade as assessed by reduction in exercise heart rate, and all increased the left-ventricular ejection fraction. Compared with the β1-selective, second-generation compound metoprolol, the third-generation compounds bucindolol and carvedilol lowered indices of adrenergic activity and tended to improve LV function to a greater extent. In patients with chronic heart failure there may be important therapeutic response differences between second- and third-generation beta-blocking agents.
Original language | English (US) |
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Pages (from-to) | 291-296 |
Number of pages | 6 |
Journal | Cardiovascular Drugs and Therapy |
Volume | 11 |
Issue number | SUPPL. 1 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
Keywords
- Antiadrenergic activity
- Beta-blocking drugs
- Chronic heart failure
- Exercise response
- Idiopathic dilated cardiomyopathy
- Ischemic cardiomyopathy
- Left ventricular function
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine
- Pharmacology (medical)