Secondary acute lymphoblastic leukemia is an independent predictor of poor prognosis

Smith Giri, Michelle Chi, Benny Johnson, David McCormick, Omer Jamy, Vijaya Raj Bhatt, Mike G. Martin

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Compared to secondary acute myeloid leukemia, secondary acute lymphoblastic leukemia (sALL) is poorly characterized. We utilized data from the Surveillance, Epidemiology, and End Results (SEER) 13 database to further elucidate patient characteristics and prognostic factors in sALL. Cases of adult de novo acute lymphoblastic leukemia (ALL) and sALL in patients with primary breast, rectum, cervix, or ovarian cancers or lymphoma with a latency period of at least 12 months were identified within the SEER 13 database. Survival in sALL and de novo ALL were compared after propensity matching based on age, gender, race, ALL subtype, and year of diagnosis. 4124 cases of de novo ALL and 79 cases of sALL were identified. sALL patients were older at diagnosis (median 62 years vs 44 years; p < 0.01). Overall survival (OS) in sALL was lower than de novo ALL (median 8 months vs 11 months), 1 year OS: 35% vs 47% (p = 0.05), 2 year OS: 16% vs 31% (p < 0.01), and 5 year OS: 7% vs 21% (p < 0.01). Multivariate analysis revealed sALL as an independent predictor of worsened survival (adjusted HR 1.54; 95% CI 1.16-2.04, p < 0.01) after propensity matching.

Original languageEnglish (US)
Pages (from-to)1342-1346
Number of pages5
JournalLeukemia Research
Volume39
Issue number12
DOIs
StatePublished - Jul 1 2015

Keywords

  • Prognosis
  • Secondary leukemia
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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